Renal dysfunction and accuracy of N-terminal pro-B-type natriuretic peptide in predicting mortality for hospitalized patients with heart failure

Domenico Scrutinio, Filippo Mastropasqua, Pietro Guida, Enrico Ammirati, Vitoantonio Ricci, Rosa Raimondo, Maria Frigerio, Rocco Lagioia, Fabrizio Oliva

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Background: Renal dysfunction may confound the clinical interpretation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration. This study investigated whether renal dysfunction influences the prognostic accuracy of NT-proBNP in acute decompensated heart failure (ADHF).

Methods and Results: We studied 908 ADHF patients. The primary outcome was 12-month mortality. Interaction between estimated glomerular filtration rate (eGFR) and NT-proBNP in predicting mortality was tested with the likelihood ratio test. The patients were classified into 3 eGFR strata: ≥60, 30-59, and 5,180 pg/ml was 2.09 (P

Conclusions: There was no evidence of interaction between eGFR and NT-proBNP in predicting mortality. The NT-proBNP cut-off of 5,180 ng/L provided independent prognostic information, irrespective of the level of residual renal function.

Original languageEnglish
Pages (from-to)2439-2446
Number of pages8
JournalCirculation Journal
Issue number10
Publication statusPublished - 2014



  • Acute decompensated heart failure
  • Mortality
  • N-terminal pro-B-type natriuretic peptide
  • Prognosis
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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