Renal dysfunction and accuracy of N-terminal pro-B-type natriuretic peptide in predicting mortality for hospitalized patients with heart failure

Domenico Scrutinio, Filippo Mastropasqua, Pietro Guida, Enrico Ammirati, Vitoantonio Ricci, Rosa Raimondo, Maria Frigerio, Rocco Lagioia, Fabrizio Oliva

Research output: Contribution to journalArticle

Abstract

Background: Renal dysfunction may confound the clinical interpretation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration. This study investigated whether renal dysfunction influences the prognostic accuracy of NT-proBNP in acute decompensated heart failure (ADHF).

Methods and Results: We studied 908 ADHF patients. The primary outcome was 12-month mortality. Interaction between estimated glomerular filtration rate (eGFR) and NT-proBNP in predicting mortality was tested with the likelihood ratio test. The patients were classified into 3 eGFR strata: ≥60, 30-59, and 5,180 pg/ml was 2.09 (P

Conclusions: There was no evidence of interaction between eGFR and NT-proBNP in predicting mortality. The NT-proBNP cut-off of 5,180 ng/L provided independent prognostic information, irrespective of the level of residual renal function.

Original languageEnglish
Pages (from-to)2439-2446
Number of pages8
JournalCirculation Journal
Volume78
Issue number10
DOIs
Publication statusPublished - 2014

Keywords

  • Acute decompensated heart failure
  • Mortality
  • N-terminal pro-B-type natriuretic peptide
  • Prognosis
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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