Renal effects of felodipine in hypertension

G. Leonetti, L. Terzoli, L. Rupoli, R. Gradnik, A. Zanchetti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The results of 2 recent studies on the renal effects of felodipine in hypertensive patients are described. Antihypertensive doses of felodipine (10 mg bid) displayed a clear natriuretic and diuretic effect associated with a constant glomerular filtration rate and an increase in renal plasma flow. With higher doses of felodipine (up to 50 mg tid), the natriuretic effect was reversed to an antinatriuretic effect, accompanied by a reduction in glomerular filtration rate. The natriuretic effect of felodipine 10 mg bid was evident during the first 2 days of administration, but a negative sodium balance was still present at the end of the seventh day. The mechanisms of the renal effects of calcium antagonists are discussed as well as the relevance of the natriuretic effect for the antihypertensive action of these compounds.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalDrugs
Volume35
Issue number1
Publication statusPublished - 1988

Fingerprint

Felodipine
Natriuretic Agents
Hypertension
Kidney
Glomerular Filtration Rate
Antihypertensive Agents
Renal Plasma Flow
Plasma flow
Diuretics
Sodium
Calcium

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Leonetti, G., Terzoli, L., Rupoli, L., Gradnik, R., & Zanchetti, A. (1988). Renal effects of felodipine in hypertension. Drugs, 35(1), 59-66.

Renal effects of felodipine in hypertension. / Leonetti, G.; Terzoli, L.; Rupoli, L.; Gradnik, R.; Zanchetti, A.

In: Drugs, Vol. 35, No. 1, 1988, p. 59-66.

Research output: Contribution to journalArticle

Leonetti, G, Terzoli, L, Rupoli, L, Gradnik, R & Zanchetti, A 1988, 'Renal effects of felodipine in hypertension', Drugs, vol. 35, no. 1, pp. 59-66.
Leonetti G, Terzoli L, Rupoli L, Gradnik R, Zanchetti A. Renal effects of felodipine in hypertension. Drugs. 1988;35(1):59-66.
Leonetti, G. ; Terzoli, L. ; Rupoli, L. ; Gradnik, R. ; Zanchetti, A. / Renal effects of felodipine in hypertension. In: Drugs. 1988 ; Vol. 35, No. 1. pp. 59-66.
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