Renal Failure: A Modern Semiology for an Old Disease

Michelangelo Nasuto, Vittorio Pansini, Bernard Cortet, Giuseppe Guglielmi, Anne Cotten

Research output: Contribution to journalArticlepeer-review


Chronic kidney disease (CKD) is a complex systemic disease that induces mineral metabolic dysfunction leading to bone fragility and tissue calcifications. Bone abnormalities in CKD can include increased bone turnover and resorption due to secondary hyperparathyroidism, decreased bone turnover and bone formation, defective bone mineralization, or a mixed pattern of these abnormalities. Other features of musculoskeletal involvement include synovial, tendon, and ligament thickening due to β2-microglobulin amyloidosis, soft tissue masses, or axial and peripheral arthropathies. The accurate assessment of bone involvement in early-stage CKD is crucial for the success of therapeutic interventions. We summarize the key semiologic features of bone abnormalities in CKD and review musculoskeletal complications as depicted by conventional radiography, computed tomography, magnetic resonance, and ultrasound imaging. We also discuss different experimental diagnostic approaches developed for the purpose of identifying changes in bone quality and structure in early-stage CKD.

Original languageEnglish
Pages (from-to)353-368
Number of pages16
JournalSeminars in Musculoskeletal Radiology
Issue number4
Publication statusPublished - Sep 1 2016


  • bone
  • bone resorption
  • chronic kidney disease-mineral and bone disorder
  • magnetic resonance imaging
  • renal failure

ASJC Scopus subject areas

  • Medicine(all)
  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Renal Failure: A Modern Semiology for an Old Disease'. Together they form a unique fingerprint.

Cite this