Renal fibrosis and proteomics: Current knowledge and still key open questions for proteomic investigation

Marco Prunotto, GianMarco Ghiggeri, Maurizio Bruschi, Giulio Gabbiani, Pierre Lescuyer, Berthold Hocher, Lyubov Chaykovska, Marco Berrera, Solange Moll

Research output: Contribution to journalArticlepeer-review

Abstract

Renal tubulo-interstitial fibrosis is a non-specific process, representing the final common pathway for all kidney diseases, irrespective of their initial cause, histological injury, or etiology, leading to gradual expansion of the fibrotic mass which destroys the normal structure of the tissue and results in organ dysfunction and, ultimately, in end-stage organ failure. Proteomic studies of the fibrotic pathophysiological mechanisms have been performed in cell cultures, animal models and human tissues, addressing some of the key issues. This article will review proteomic contribution to the raising current knowledge on renal fibrosis biology and also mention seminal open questions to which proteomic techniques and proteomists could fruitfully contribute.

Original languageEnglish
Pages (from-to)1855-1870
Number of pages16
JournalJournal of Proteomics
Volume74
Issue number10
DOIs
Publication statusPublished - Sep 6 2011

Keywords

  • CKD
  • Drug discovery
  • Fibrosis
  • Kidney
  • Myofibroblast
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

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