Renal function in pregnant rats with two-kidney goldblatt hypertension.

A. Dal Canton, M. Sabbatini, C. Esposito, M. Altomonte, G. Romano, F. Uccello, G. Conte, G. Fuiano, D. Russo, V. E. Andreucci

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Abstract

This study was carried out in female Wistar-Münich rats with two-kidney, one-clip hypertension, using clipped normotensive rats as controls. Metabolic studies were performed in the first two weeks of pregnancy, consisting of daily measurement of systolic blood pressure (BP) (tail-cuff), body weight (BW), and salt and water balance. At the end of metabolic studies, glomerular dynamics were studied in the unclipped kidney by micropuncture. During pregnancy, urinary output of Na+ and water was greater in hypertensive than normotensive rats. The greater natriuresis accounted for a reduced Na+ retention and a lower increase in maternal BW. Micropuncture studies showed an impaired renal auto-regulation. These results show that hypertension in pregnancy causes a salt-losing tendency, that may be secondary to incomplete renal autoregulation.

Original languageEnglish
Pages (from-to)499-506
Number of pages8
JournalProceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
Volume20
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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    Dal Canton, A., Sabbatini, M., Esposito, C., Altomonte, M., Romano, G., Uccello, F., Conte, G., Fuiano, G., Russo, D., & Andreucci, V. E. (1983). Renal function in pregnant rats with two-kidney goldblatt hypertension. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 20, 499-506.