Renal haemodynamics are not related to genotypes in offspring of parents with essential hypertension

Karin Skov, Jens Kristian Madsen, Hans Erik Hansen, Laura Zagato, Erik Frandsen, Giuseppe Bianchi, Michael John Mulvany

Research output: Contribution to journalArticle

Abstract

Introduction. The pathogenesis of essential hypertension (EH) has a major genetic component and is associated with renal abnormalities. Normotensive offspring of hypertensive parents are likely to develop EH and are a suitable population for identifying possible relations between genetic and renal abnormalities. Methods. We investigated if renin-angiotensin-aldosterone system associated genotypes (angiotensinogen [M235T] and ACE [I/D]) are related to blood pressure (BP), renal haemodynamics and sodium excretion in sex and age-matched (18-35 years) healthy Caucasian offspring of either two parents with EH (n=101, EH-offspring) or two normotensive parents (n=50, controls). The alpha-adducin polymorphism (G460W) was also investigated. Results. Compared to controls, BP, heart rate, renal vascular resistance (RVR) and urinary sodium excretion were, respectively, 5%, 7%, 15% and 20% higher in EH-offspring. In controls, the TT-genotype of the M235T angiotensinogen polymorphism was associated with higher BP and higher plasma angiotensinogen. By contrast, in EH-offspring the TT-genotype was associated with lower BP and unchanged plasma angiotensinogen. Plasma angiotensinogen correlated positively with BP in EH-offspring, with a similar tendency (p=0.08) in controls. The distributions of the three candidate polymorphisms were similar in EH-offspring and controls. There were no associations between any of the polymorphisms and any of the renal parameters measured. Conclusion. The markedly greater RVR, proportionally larger than the greater BP, supports a role for RVR in the pathogenesis of EH. The lack of association between the candidate polymorphisms and the investigated parameters, even in this homogenous and for hypertension strongly predisposed group, suggests that the polymorphisms investigated do not play important roles in the pathogenesis of hypertension.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume7
Issue number1
DOIs
Publication statusPublished - Mar 2006

    Fingerprint

Keywords

  • Blood pressure
  • Genetics
  • Haemodynamics
  • Offspring

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this