Renal impairment in chronic cigarette smokers

Giovanni Gambaro, Fabio Verlato, Alessandro Budakovic, Dario Casara, Giorgio Saladini, Dorella Del Prete, Giselda Bertaglia, Maurizio Masiero, Simone Checchetto, Bruno Baggio

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the effect of chronic cigarette smoking on renal function, a cross-sectional study was carried out with 30 subjects who had no known vascular disease risk factor other than cigarette smoking, and 24 age- and sex-matched controls without any vascular risk factor including cigarette smoking. Renal function by radionuclide studies of renal plasma flow, GFR, and plasma endothelin-1 concentration was determined. Compared with nonsmokers, smokers had a renal function impairment characterized by a normal GFR and a significant reduction in renal plasma flow as reflected by MAG3 clearance (199.20 ± 58.85 ml/min per 1.73 m2 versus 256.54 ± 60.14 ml/min per 1.73 m2; t = 3.52, P <0.001). MAG3 clearance was significantly correlated with age and smoking. The renal dysfunction was associated with an increase in plasma endothelin-1 concentration (21.56 ± 1.15 pmol/L versus 25.01 ± 3.21 pmol/L; t = 5.00, P <0.001). Former smokers as well had similar, although milder, abnormalities. In conclusion, cigarette smokers manifest an impairment of renal function, suggesting that smoke may have a detrimental effect on renal function.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalJournal of the American Society of Nephrology
Volume9
Issue number4
Publication statusPublished - Apr 1998

ASJC Scopus subject areas

  • Nephrology

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