Abstract
BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate
| Original language | English |
|---|---|
| Pages (from-to) | 1211-1217 |
| Number of pages | 7 |
| Journal | Circulation |
| Volume | 115 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Mar 2007 |
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Keywords
- Angiography
- Angioplasty
- Complications
- Contrast media
- Kidney
- Prevention
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Renal insufficiency following contrast media administration trial (REMEDIAL) : A randomized comparison of 3 preventive strategies. / Briguori, Carlo; Airoldi, Flavio; D'Andrea, Davide; Bonizzoni, Erminio; Morici, Nuccia; Focaccio, Amelia; Michev, Iassen; Montorfano, Matteo; Carlino, Mauro; Cosgrave, John; Ricciardelli, Bruno; Colombo, Antonio.
In: Circulation, Vol. 115, No. 10, 03.2007, p. 1211-1217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Renal insufficiency following contrast media administration trial (REMEDIAL)
T2 - A randomized comparison of 3 preventive strategies
AU - Briguori, Carlo
AU - Airoldi, Flavio
AU - D'Andrea, Davide
AU - Bonizzoni, Erminio
AU - Morici, Nuccia
AU - Focaccio, Amelia
AU - Michev, Iassen
AU - Montorfano, Matteo
AU - Carlino, Mauro
AU - Cosgrave, John
AU - Ricciardelli, Bruno
AU - Colombo, Antonio
PY - 2007/3
Y1 - 2007/3
N2 - BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate
AB - BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate
KW - Angiography
KW - Angioplasty
KW - Complications
KW - Contrast media
KW - Kidney
KW - Prevention
UR - http://www.scopus.com/inward/record.url?scp=33947716173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947716173&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.106.687152
DO - 10.1161/CIRCULATIONAHA.106.687152
M3 - Article
C2 - 17309916
AN - SCOPUS:33947716173
VL - 115
SP - 1211
EP - 1217
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 10
ER -