Abstract
BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate
Original language | English |
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Pages (from-to) | 1211-1217 |
Number of pages | 7 |
Journal | Circulation |
Volume | 115 |
Issue number | 10 |
DOIs | |
Publication status | Published - Mar 2007 |
Keywords
- Angiography
- Angioplasty
- Complications
- Contrast media
- Kidney
- Prevention
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine