Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies

Carlo Briguori; Flavio Airoldi; Davide D'Andrea; Erminio Bonizzoni; Nuccia Morici; Amelia Focaccio; Iassen Michev; Matteo Montorfano; Mauro Carlino; John Cosgrave; Bruno Ricciardelli; Antonio Colombo

doi:10.1161/CIRCULATIONAHA.106.687152

Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies

Carlo Briguori, Flavio Airoldi, Davide D'Andrea, Erminio Bonizzoni, Nuccia Morici, Amelia Focaccio, Iassen Michev, Matteo Montorfano, Mauro Carlino, John Cosgrave, Bruno Ricciardelli, Antonio Colombo

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate

Original language	English
Pages (from-to)	1211-1217
Number of pages	7
Journal	Circulation
Volume	115
Issue number	10
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.106.687152
Publication status	Published - Mar 2007

Keywords

Angiography
Angioplasty
Complications
Contrast media
Kidney
Prevention

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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Briguori, C., Airoldi, F., D'Andrea, D., Bonizzoni, E., Morici, N., Focaccio, A., Michev, I., Montorfano, M., Carlino, M., Cosgrave, J., Ricciardelli, B., & Colombo, A. (2007). Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies. Circulation, 115(10), 1211-1217. https://doi.org/10.1161/CIRCULATIONAHA.106.687152

Renal insufficiency following contrast media administration trial (REMEDIAL) : A randomized comparison of 3 preventive strategies. / Briguori, Carlo; Airoldi, Flavio; D'Andrea, Davide; Bonizzoni, Erminio; Morici, Nuccia; Focaccio, Amelia; Michev, Iassen; Montorfano, Matteo ; Carlino, Mauro; Cosgrave, John; Ricciardelli, Bruno; Colombo, Antonio.

In: Circulation, Vol. 115, No. 10, 03.2007, p. 1211-1217.

Research output: Contribution to journal › Article › peer-review

Briguori, C, Airoldi, F, D'Andrea, D, Bonizzoni, E, Morici, N, Focaccio, A, Michev, I, Montorfano, M , Carlino, M, Cosgrave, J, Ricciardelli, B & Colombo, A 2007, 'Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies', Circulation, vol. 115, no. 10, pp. 1211-1217. https://doi.org/10.1161/CIRCULATIONAHA.106.687152

Briguori, Carlo ; Airoldi, Flavio ; D'Andrea, Davide ; Bonizzoni, Erminio ; Morici, Nuccia ; Focaccio, Amelia ; Michev, Iassen ; Montorfano, Matteo ; Carlino, Mauro ; Cosgrave, John ; Ricciardelli, Bruno ; Colombo, Antonio. / Renal insufficiency following contrast media administration trial (REMEDIAL) : A randomized comparison of 3 preventive strategies. In: Circulation. 2007 ; Vol. 115, No. 10. pp. 1211-1217.

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abstract = "BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate ",

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author = "Carlo Briguori and Flavio Airoldi and Davide D'Andrea and Erminio Bonizzoni and Nuccia Morici and Amelia Focaccio and Iassen Michev and Matteo Montorfano and Mauro Carlino and John Cosgrave and Bruno Ricciardelli and Antonio Colombo",

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AU - Bonizzoni, Erminio

AU - Morici, Nuccia

AU - Focaccio, Amelia

AU - Michev, Iassen

AU - Montorfano, Matteo

AU - Carlino, Mauro

AU - Cosgrave, John

AU - Ricciardelli, Bruno

AU - Colombo, Antonio

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KW - Angiography

KW - Angioplasty

KW - Complications

KW - Contrast media

KW - Kidney

KW - Prevention

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