Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies

Carlo Briguori, Flavio Airoldi, Davide D'Andrea, Erminio Bonizzoni, Nuccia Morici, Amelia Focaccio, Iassen Michev, Matteo Montorfano, Mauro Carlino, John Cosgrave, Bruno Ricciardelli, Antonio Colombo

Research output: Contribution to journalArticle

Abstract

BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalCirculation
Volume115
Issue number10
DOIs
Publication statusPublished - Mar 2007

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Acetylcysteine
Contrast Media
Renal Insufficiency
Sodium Bicarbonate
Ascorbic Acid
Glomerular Filtration Rate
Chronic Renal Insufficiency
Creatinine
Serum

Keywords

  • Angiography
  • Angioplasty
  • Complications
  • Contrast media
  • Kidney
  • Prevention

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Renal insufficiency following contrast media administration trial (REMEDIAL) : A randomized comparison of 3 preventive strategies. / Briguori, Carlo; Airoldi, Flavio; D'Andrea, Davide; Bonizzoni, Erminio; Morici, Nuccia; Focaccio, Amelia; Michev, Iassen; Montorfano, Matteo; Carlino, Mauro; Cosgrave, John; Ricciardelli, Bruno; Colombo, Antonio.

In: Circulation, Vol. 115, No. 10, 03.2007, p. 1211-1217.

Research output: Contribution to journalArticle

Briguori, C, Airoldi, F, D'Andrea, D, Bonizzoni, E, Morici, N, Focaccio, A, Michev, I, Montorfano, M, Carlino, M, Cosgrave, J, Ricciardelli, B & Colombo, A 2007, 'Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies', Circulation, vol. 115, no. 10, pp. 1211-1217. https://doi.org/10.1161/CIRCULATIONAHA.106.687152
Briguori, Carlo ; Airoldi, Flavio ; D'Andrea, Davide ; Bonizzoni, Erminio ; Morici, Nuccia ; Focaccio, Amelia ; Michev, Iassen ; Montorfano, Matteo ; Carlino, Mauro ; Cosgrave, John ; Ricciardelli, Bruno ; Colombo, Antonio. / Renal insufficiency following contrast media administration trial (REMEDIAL) : A randomized comparison of 3 preventive strategies. In: Circulation. 2007 ; Vol. 115, No. 10. pp. 1211-1217.
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AU - D'Andrea, Davide

AU - Bonizzoni, Erminio

AU - Morici, Nuccia

AU - Focaccio, Amelia

AU - Michev, Iassen

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AU - Carlino, Mauro

AU - Cosgrave, John

AU - Ricciardelli, Bruno

AU - Colombo, Antonio

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KW - Complications

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