Renal insufficiency following contrast media administration trial (REMEDIAL): A randomized comparison of 3 preventive strategies

Carlo Briguori, Flavio Airoldi, Davide D'Andrea, Erminio Bonizzoni, Nuccia Morici, Amelia Focaccio, Iassen Michev, Matteo Montorfano, Mauro Carlino, John Cosgrave, Bruno Ricciardelli, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND - Volume supplementation by saline infusion combined with N-acetylcysteine (NAC) represents an effective strategy to prevent contrast agent-induced nephrotoxicity (CIN). Preliminary data support the concept that sodium bicarbonate and ascorbic acid also may be effective in preventing CIN. METHODS AND RESULTS - Three hundred twenty-six consecutive patients with chronic kidney disease, referred to our institutions for coronary and/or peripheral procedures, were randomly assigned to prophylactic administration of 0.9% saline infusion plus NAC (n=111), sodium bicarbonate infusion plus NAC (n=108), and 0.9% saline plus ascorbic acid plus NAC (n=107). All enrolled patients had serum creatinine ≥2.0 mg/dL and/or estimated glomerular filtration rate

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalCirculation
Volume115
Issue number10
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Angiography
  • Angioplasty
  • Complications
  • Contrast media
  • Kidney
  • Prevention

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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