Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases

G. Barbiano di Belgiojoso, S. Bertoli, A. Tarantino, G. Colasanti, M. Bosisio-Bestetti, F. Ferrario, G. Montagnino, G. Banfi, A. Bucci, M. Surian, G. Colussi, L. Guerra, G. Micoli

Research output: Contribution to journalArticle

Abstract

56 renal biopsies in 48 patients affected by essential mixed IgG-IgM cryoglobulinemia have been examined by light microscopy and immunofluorescence. Patients were classified in four groups: 1) minimal lesions (4 patients); 2) pure proliferative mesangial lesions (9 patients); 3) membranoproliferative glomerulonephritis (23 patients); 4) proliferative glomerulonephritis with prominent intraluminal thrombi (12 patients). In this last group large intraluminal thrombi intensely fixing anti-IgG and IgM antisera were present; unlike the preceding groups, few deposits on capillary walls were seen. These four groups differed in renal clinical syndrome at presentation: in particular, proteinuria or nephrotic syndrome was the predominant manifestation in group 3, acute nephritic syndrome in group 4. In the latter, reversal of renal failure and regression of lesions could be observed. Various morphological aspects tend to show that in this disease more than one mechanism is operating in producing renal damage, including local trapping of abnormal circulating proteins.

Original languageEnglish
Pages (from-to)316-327
Number of pages12
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume60
Issue number4
Publication statusPublished - 1981

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Cryoglobulinemia
Immunoglobulin M
Immunoglobulin G
Kidney
Thrombosis
Membranoproliferative Glomerulonephritis
Nephrotic Syndrome
Glomerulonephritis
Proteinuria
Fluorescence Microscopy
Renal Insufficiency
Immune Sera
Biopsy
Light
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Barbiano di Belgiojoso, G., Bertoli, S., Tarantino, A., Colasanti, G., Bosisio-Bestetti, M., Ferrario, F., ... Micoli, G. (1981). Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases. Bollettino dell'Istituto Sieroterapico Milanese, 60(4), 316-327.

Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases. / Barbiano di Belgiojoso, G.; Bertoli, S.; Tarantino, A.; Colasanti, G.; Bosisio-Bestetti, M.; Ferrario, F.; Montagnino, G.; Banfi, G.; Bucci, A.; Surian, M.; Colussi, G.; Guerra, L.; Micoli, G.

In: Bollettino dell'Istituto Sieroterapico Milanese, Vol. 60, No. 4, 1981, p. 316-327.

Research output: Contribution to journalArticle

Barbiano di Belgiojoso, G, Bertoli, S, Tarantino, A, Colasanti, G, Bosisio-Bestetti, M, Ferrario, F, Montagnino, G, Banfi, G, Bucci, A, Surian, M, Colussi, G, Guerra, L & Micoli, G 1981, 'Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases', Bollettino dell'Istituto Sieroterapico Milanese, vol. 60, no. 4, pp. 316-327.
Barbiano di Belgiojoso G, Bertoli S, Tarantino A, Colasanti G, Bosisio-Bestetti M, Ferrario F et al. Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases. Bollettino dell'Istituto Sieroterapico Milanese. 1981;60(4):316-327.
Barbiano di Belgiojoso, G. ; Bertoli, S. ; Tarantino, A. ; Colasanti, G. ; Bosisio-Bestetti, M. ; Ferrario, F. ; Montagnino, G. ; Banfi, G. ; Bucci, A. ; Surian, M. ; Colussi, G. ; Guerra, L. ; Micoli, G. / Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases. In: Bollettino dell'Istituto Sieroterapico Milanese. 1981 ; Vol. 60, No. 4. pp. 316-327.
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AU - Colasanti, G.

AU - Bosisio-Bestetti, M.

AU - Ferrario, F.

AU - Montagnino, G.

AU - Banfi, G.

AU - Bucci, A.

AU - Surian, M.

AU - Colussi, G.

AU - Guerra, L.

AU - Micoli, G.

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N2 - 56 renal biopsies in 48 patients affected by essential mixed IgG-IgM cryoglobulinemia have been examined by light microscopy and immunofluorescence. Patients were classified in four groups: 1) minimal lesions (4 patients); 2) pure proliferative mesangial lesions (9 patients); 3) membranoproliferative glomerulonephritis (23 patients); 4) proliferative glomerulonephritis with prominent intraluminal thrombi (12 patients). In this last group large intraluminal thrombi intensely fixing anti-IgG and IgM antisera were present; unlike the preceding groups, few deposits on capillary walls were seen. These four groups differed in renal clinical syndrome at presentation: in particular, proteinuria or nephrotic syndrome was the predominant manifestation in group 3, acute nephritic syndrome in group 4. In the latter, reversal of renal failure and regression of lesions could be observed. Various morphological aspects tend to show that in this disease more than one mechanism is operating in producing renal damage, including local trapping of abnormal circulating proteins.

AB - 56 renal biopsies in 48 patients affected by essential mixed IgG-IgM cryoglobulinemia have been examined by light microscopy and immunofluorescence. Patients were classified in four groups: 1) minimal lesions (4 patients); 2) pure proliferative mesangial lesions (9 patients); 3) membranoproliferative glomerulonephritis (23 patients); 4) proliferative glomerulonephritis with prominent intraluminal thrombi (12 patients). In this last group large intraluminal thrombi intensely fixing anti-IgG and IgM antisera were present; unlike the preceding groups, few deposits on capillary walls were seen. These four groups differed in renal clinical syndrome at presentation: in particular, proteinuria or nephrotic syndrome was the predominant manifestation in group 3, acute nephritic syndrome in group 4. In the latter, reversal of renal failure and regression of lesions could be observed. Various morphological aspects tend to show that in this disease more than one mechanism is operating in producing renal damage, including local trapping of abnormal circulating proteins.

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