Renal Regeneration: The Bioengineering Approach

Marcus Salvatori, Andrea Peloso, Timil Patel, Sij Hemal, Joao Paulo Zambon, Ravi Katari, Giuseppe Orlando

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The prevalence of chronic kidney disease continues to outpace the development of effective treatment strategies. For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions. Allogeneic transplantation remains the only restorative treatment, but donor shortage, surgical morbidity, and the need for lifelong immunosuppression significantly limit clinical application. Emerging technologies in the fields of regenerative medicine and tissue engineering strive to address these limitations. In the present chapter, we will illustrate the recent advances in kidney bioengineering and regeneration with an emphasis to the bioengineering approach. Collaborative efforts aim to produce a bioengineered kidney capable of restoring renal function in patients with end-stage disease.

Original languageEnglish
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages227-239
Number of pages13
ISBN (Print)9780123985231
DOIs
Publication statusPublished - 2014

Keywords

  • Cell
  • Extracellular matrix
  • Kidney bioengineering
  • Organ transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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