TY - JOUR
T1 - Renal resistive index early detects chronic tubulointerstitial nephropathy in normo- and hypertensive patients
AU - Boddi, Maria
AU - Cecioni, Ilaria
AU - Poggesi, Loredana
AU - Fiorentino, Francesca
AU - Olianti, Katia
AU - Berardino, Sabino
AU - La Cava, Giuseppe
AU - Gensini, GianFranco
PY - 2006/4
Y1 - 2006/4
N2 - Background: We studied whether the measurement of intrarenal vascular resistance by Doppler ultrasonography, capable of investigating renal interstitial compartment, allows the early detection of chronic tubulointerstitial nephropathy (TIN). Methods: 30 normotensive and 28 hypertensive (I-II OMS) patients with a clinical history suggestive of chronic TIN and normal renal function were enrolled. 40 healthy volunteers served as controls. Patients were considered TIN-negative or TIN-positive after investigating tubular function by urine concentrating and acidification tests. Renal sonographic parameters and renal resistive index (RRI) were obtained by duplex scanner. Glomerular filtration rate/effective renal plasmatic flow ratio was investigated by sequential renal scintigraphy in TIN-negative and TIN-positive patients; 99mTc-DMSA scintigraphy was also performed in TIN-positive patients. Results: RRI values of TIN-positive normotensive and hypertensive patients were significantly higher (p <0.01 for both) than those of TIN-negative patients and of controls. RRI values resulted to be linearly related to uricemia (r = 0.88, p <0.0001) only in normotensive patients. RRI values also resulted to be linearly related to filtration ratio values (r = 0.60, p <0.0001). 99mTc-DMSA scintigraphy confirmed interstitial renal damage (grade 1 and 2). Conclusion: RRI measurement allows the early identification of both normotensive and hypertensive patients with chronic TIN and signs of tubular dysfunction, when renal function is still preserved.
AB - Background: We studied whether the measurement of intrarenal vascular resistance by Doppler ultrasonography, capable of investigating renal interstitial compartment, allows the early detection of chronic tubulointerstitial nephropathy (TIN). Methods: 30 normotensive and 28 hypertensive (I-II OMS) patients with a clinical history suggestive of chronic TIN and normal renal function were enrolled. 40 healthy volunteers served as controls. Patients were considered TIN-negative or TIN-positive after investigating tubular function by urine concentrating and acidification tests. Renal sonographic parameters and renal resistive index (RRI) were obtained by duplex scanner. Glomerular filtration rate/effective renal plasmatic flow ratio was investigated by sequential renal scintigraphy in TIN-negative and TIN-positive patients; 99mTc-DMSA scintigraphy was also performed in TIN-positive patients. Results: RRI values of TIN-positive normotensive and hypertensive patients were significantly higher (p <0.01 for both) than those of TIN-negative patients and of controls. RRI values resulted to be linearly related to uricemia (r = 0.88, p <0.0001) only in normotensive patients. RRI values also resulted to be linearly related to filtration ratio values (r = 0.60, p <0.0001). 99mTc-DMSA scintigraphy confirmed interstitial renal damage (grade 1 and 2). Conclusion: RRI measurement allows the early identification of both normotensive and hypertensive patients with chronic TIN and signs of tubular dysfunction, when renal function is still preserved.
KW - Doppler ultrasound
KW - Essential hypertension
KW - Renal resistive index
KW - Tubulointerstitial nephropathy
UR - http://www.scopus.com/inward/record.url?scp=33645673195&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645673195&partnerID=8YFLogxK
U2 - 10.1159/000090786
DO - 10.1159/000090786
M3 - Article
C2 - 16401882
AN - SCOPUS:33645673195
VL - 26
SP - 16
EP - 21
JO - American Journal of Nephrology
JF - American Journal of Nephrology
SN - 0250-8095
IS - 1
ER -