Renal toxicity of anticancer agents targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs)

Laura Cosmai, Maurizio Gallieni, Wanda Liguigli, Camillo Porta

Research output: Contribution to journalReview article

Abstract

Since angiogenesis plays a key role in tumor growth, progression and metastasization, anti-vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) agents have been developed over the years as anticancer agents, and have changed, for the better, the natural history of a number of cancer types. In the present review, the renal safety profile of presently available agents targeting either VEGF or VEGFRs will be discussed, together with the peculiarities related to their clinical use in patients with impaired renal function, or even in dialysis. Indeed, renal toxicity (especially, but not exclusively, hypertension and proteinuria) are quite commonly observed with these agents, and may be increased by the concomitant use of cytoxic chemotherapeutics. Despite all the above, kidney impairment or dialysis must not be regarded di per se as reasons not to administer or to stop an active anticancer treatment, especially considering the possibility of a significant survival improvement in many cancer patients treated with these agents.

Original languageEnglish
Pages (from-to)171-180
Number of pages10
JournalJournal of Nephrology
Volume30
Issue number2
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Antiangiogenic agents
  • Hypertension
  • Proteinuria
  • Renal toxicity
  • VEGF
  • VEGFR

ASJC Scopus subject areas

  • Nephrology

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