Abstract
278 azathioprine and methylprednisolone (AZA)-treated and 406 ciclosporin (CS) treated patients with a kidney graft functioning for more than 1 year were investigated for the presence of chronic liver disease (CLD), defined as an increase in transaminases of 1.5 times the upper normal limits for a period of at least 12 months. The prevalence of CLD was 36 and 27% in the two groups, respectively. The univariate analysis showed that male sex, alcohol abuse and HBsAg positivity correlated with CLD onset in the AZA group while blood transfusions, length of dialysis treatment, pretransplantation CLD, HBsAg positivity and ferritin levels over 800 ng/ml correlated with CLD onset in CS. The multivariate analysis identified male sex and HBsAg positivity in the AZA group and age over 18 years, high ferritin levels and HBsAg positivity in the CS group as risk factors predictive of CLD onset. Liver failure represented the 4th cause of death in the AZA group but 1 of the 2 most important causes of death in CS in the long term. However, these drawbacks were overcome by the overall low mortality rate in CS. Therefore, renal transplantation should not be refused to patients positive for HBsAg and/or with preexisting liver disease.
| Original language | English |
|---|---|
| Pages (from-to) | 290-292 |
| Number of pages | 3 |
| Journal | Nephron |
| Volume | 61 |
| Issue number | 3 |
| Publication status | Published - 1992 |
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Keywords
- Chronic liver disease
- Graft survival
- HBV infection
- Renal transplantation
ASJC Scopus subject areas
- Nephrology
Cite this
Renal transplant recipients and chronic liver disease : Statistical evaluation of predisposing factors. / Aroldi, A.; Tarantino, A.; Montagnino, G.; Paparella, M.; Cesana, B.; Rumi, M. G.; Ponticelli, C.
In: Nephron, Vol. 61, No. 3, 1992, p. 290-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Renal transplant recipients and chronic liver disease
T2 - Statistical evaluation of predisposing factors
AU - Aroldi, A.
AU - Tarantino, A.
AU - Montagnino, G.
AU - Paparella, M.
AU - Cesana, B.
AU - Rumi, M. G.
AU - Ponticelli, C.
PY - 1992
Y1 - 1992
N2 - 278 azathioprine and methylprednisolone (AZA)-treated and 406 ciclosporin (CS) treated patients with a kidney graft functioning for more than 1 year were investigated for the presence of chronic liver disease (CLD), defined as an increase in transaminases of 1.5 times the upper normal limits for a period of at least 12 months. The prevalence of CLD was 36 and 27% in the two groups, respectively. The univariate analysis showed that male sex, alcohol abuse and HBsAg positivity correlated with CLD onset in the AZA group while blood transfusions, length of dialysis treatment, pretransplantation CLD, HBsAg positivity and ferritin levels over 800 ng/ml correlated with CLD onset in CS. The multivariate analysis identified male sex and HBsAg positivity in the AZA group and age over 18 years, high ferritin levels and HBsAg positivity in the CS group as risk factors predictive of CLD onset. Liver failure represented the 4th cause of death in the AZA group but 1 of the 2 most important causes of death in CS in the long term. However, these drawbacks were overcome by the overall low mortality rate in CS. Therefore, renal transplantation should not be refused to patients positive for HBsAg and/or with preexisting liver disease.
AB - 278 azathioprine and methylprednisolone (AZA)-treated and 406 ciclosporin (CS) treated patients with a kidney graft functioning for more than 1 year were investigated for the presence of chronic liver disease (CLD), defined as an increase in transaminases of 1.5 times the upper normal limits for a period of at least 12 months. The prevalence of CLD was 36 and 27% in the two groups, respectively. The univariate analysis showed that male sex, alcohol abuse and HBsAg positivity correlated with CLD onset in the AZA group while blood transfusions, length of dialysis treatment, pretransplantation CLD, HBsAg positivity and ferritin levels over 800 ng/ml correlated with CLD onset in CS. The multivariate analysis identified male sex and HBsAg positivity in the AZA group and age over 18 years, high ferritin levels and HBsAg positivity in the CS group as risk factors predictive of CLD onset. Liver failure represented the 4th cause of death in the AZA group but 1 of the 2 most important causes of death in CS in the long term. However, these drawbacks were overcome by the overall low mortality rate in CS. Therefore, renal transplantation should not be refused to patients positive for HBsAg and/or with preexisting liver disease.
KW - Chronic liver disease
KW - Graft survival
KW - HBV infection
KW - Renal transplantation
UR - http://www.scopus.com/inward/record.url?scp=0026763088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026763088&partnerID=8YFLogxK
M3 - Article
C2 - 1501727
AN - SCOPUS:0026763088
VL - 61
SP - 290
EP - 292
JO - Experimental Nephrology
JF - Experimental Nephrology
SN - 0028-2766
IS - 3
ER -