Renal transplantation in prune-belly syndrome

Fabio Fusaro, Giovanni F. Zanon, Anna M. Ferreli, Stefano Giuliani, Graziella Zacchello, Giacomo Passerini-Glazel, Waifro Rigamonti

Research output: Contribution to journalArticlepeer-review

Abstract

We assess the effect of the prune-belly syndrome (PBS) on renal transplantation outcome. Six renal transplantations were performed in five boys affected by PBS (median age 5.8 ± 2.1 years, median weight 13.6 ± 2.4kg). Renal graft survival, graft function, lower urinary tract dysfunction, urinary tract infections (UTIs), associated complications and patients' survival after 1 and 5 years of follow-up were analysed. The rate for 1-5-year graft survival was 66.7% (mean serum creatinine 98-103 μmol/l). The surgical treatment of the documented bladder obstruction (two patients) and the severe abdominal wall deficit (one patient) led to a reduction of UTI: the patients maintained their native urinary tract and none received prophylactic antibiotics. The lack of abdominal wall musculature led to severe mechanical complication in one patient, but Monfort's abdominal wall reconstruction was able to restore the graft's function. The outcome of patients with PBS who undergo renal transplantation is good. Before the transplant, an accurate assessment of urinary tract anomalies and deficiency of the abdominal wall musculature is mandatory, to program the appropriate treatment and obtain a good long-term prognosis for the renal graft.

Original languageEnglish
Pages (from-to)549-552
Number of pages4
JournalTransplant International
Volume17
Issue number9
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Abdominal wall defect
  • Graft outcome
  • Kidney transplantation
  • Paediatrics
  • Prune-belly syndrome
  • Urinary tract infection

ASJC Scopus subject areas

  • Transplantation

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