Renal Tumors of Childhood-A Histopathologic Pattern-Based Diagnostic Approach.

Ariadne H. A. G. Ooms, Gordan M. Vujanić, Ellen D'Hooghe, Paola Collini, Aurore L'Herminé-Coulomb, Christian Vokuhl, Norbert Graf, Marry M. van den Heuvel-Eibrink, Ronald R. de Krijger

Research output: Contribution to journalArticlepeer-review

Abstract

Renal tumors comprise approximately 7 each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required.
Original languageEnglish
JournalCancers
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 1 2020

Keywords

  • oncology
  • immunohistochemistry
  • pediatric
  • molecular analysis
  • renal tumors

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