TY - JOUR
T1 - Renal Tumors of Childhood-A Histopathologic Pattern-Based Diagnostic Approach.
AU - Ooms, Ariadne H. A. G.
AU - Vujanić, Gordan M.
AU - D'Hooghe, Ellen
AU - Collini, Paola
AU - L'Herminé-Coulomb, Aurore
AU - Vokuhl, Christian
AU - Graf, Norbert
AU - Heuvel-Eibrink, Marry M. van den
AU - de Krijger, Ronald R.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Renal tumors comprise approximately 7 each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required.
AB - Renal tumors comprise approximately 7 each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required.
KW - oncology
KW - immunohistochemistry
KW - pediatric
KW - molecular analysis
KW - renal tumors
U2 - 10.3390/cancers12030729
DO - 10.3390/cancers12030729
M3 - Article
VL - 12
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 3
ER -