Renin and the sympathetic nervous system

A. Zanchetti, A. Stella

Research output: Contribution to journalArticlepeer-review


Upright tilting and intravenous furosemide seem to be very effective stimuli for sympathetic release of renin, and fruitful models by which to identify the afferent and central pathways involved. The renal nerves probably form the efferent branch of a reflex system whose afferents lie in the vagus nerve and whose receptors are stretch receptors in the cardiopulmonary area. The operation of the reflex is such that decreased stretch of the heart results in increased activity of sympathetic nerves, especially the renal nerves. This system with its probable ability to increase the release of renin and thereby to increase aldosterone production, provides an attractive, though as yet speculative, monitor and regulator of blood volume.

Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalVerhandlungen der Deutschen Gesellschaft fur Innere Medizin
VolumeNo. 80
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Internal Medicine


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