Reorganisation of the somatosensory system after early brain damage

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Objective: To examine the reorganisation of the somatosensory system after early brain lesions. Methods: We studied 12 young patients with congenital hemiplegia. Causative lesions were brain malformations, periventricular injuries and cortico-subcortical lesions. We explored the somatosensory system using evoked potentials, fMRI during sensory stimulation and clinical assessment of sensory function. To correlate sensory and motor function, we also performed transcranial magnetic stimulation, fMRI of hand movement and assessment of motor function by means of Melbourne test. Results: Eleven patients showed a perilesional reorganisation of primary somatosensory function, as expressed by short latency potentials following stimulation of the paretic hand; in a remaining patient, delayed latency responses (N27.1) were only elicited over the ipsilateral undamaged hemisphere. Five of the eleven patients with perilesional somatosensory representation of the affected hand showed contralesional shifting of motor function, thus exhibiting sensory-motor dissociation. Significant correlation was found between sensory deficit and fMRI activation during sensory stimulation. Conclusions: In subjects with early brain lesions, somato-sensory function is generally reorganised within the affected hemisphere. A contralesional shifting is uncommon and poorly efficient in function restoration. Significance: This study confirms and further explores the difference in reorganisation capabilities of the motor and sensory system following early brain injury of different etiologies and timing.

Original languageEnglish
Pages (from-to)1110-1121
Number of pages12
JournalClinical Neurophysiology
Volume118
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Hand
Magnetic Resonance Imaging
Brain
Hemiplegia
Transcranial Magnetic Stimulation
Evoked Potentials
Brain Injuries
Reaction Time
Wounds and Injuries

Keywords

  • fMRI
  • Melbourne test
  • Primary sensory cortex
  • SEPs
  • Somatosensory system

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Reorganisation of the somatosensory system after early brain damage. / Guzzetta, A.; Bonanni, P.; Biagi, L.; Tosetti, M.; Montanaro, D.; Guerrini, R.; Cioni, G.

In: Clinical Neurophysiology, Vol. 118, No. 5, 05.2007, p. 1110-1121.

Research output: Contribution to journalArticle

@article{e97cacb79b5a46d69b6b05443e4d9447,
title = "Reorganisation of the somatosensory system after early brain damage",
abstract = "Objective: To examine the reorganisation of the somatosensory system after early brain lesions. Methods: We studied 12 young patients with congenital hemiplegia. Causative lesions were brain malformations, periventricular injuries and cortico-subcortical lesions. We explored the somatosensory system using evoked potentials, fMRI during sensory stimulation and clinical assessment of sensory function. To correlate sensory and motor function, we also performed transcranial magnetic stimulation, fMRI of hand movement and assessment of motor function by means of Melbourne test. Results: Eleven patients showed a perilesional reorganisation of primary somatosensory function, as expressed by short latency potentials following stimulation of the paretic hand; in a remaining patient, delayed latency responses (N27.1) were only elicited over the ipsilateral undamaged hemisphere. Five of the eleven patients with perilesional somatosensory representation of the affected hand showed contralesional shifting of motor function, thus exhibiting sensory-motor dissociation. Significant correlation was found between sensory deficit and fMRI activation during sensory stimulation. Conclusions: In subjects with early brain lesions, somato-sensory function is generally reorganised within the affected hemisphere. A contralesional shifting is uncommon and poorly efficient in function restoration. Significance: This study confirms and further explores the difference in reorganisation capabilities of the motor and sensory system following early brain injury of different etiologies and timing.",
keywords = "fMRI, Melbourne test, Primary sensory cortex, SEPs, Somatosensory system",
author = "A. Guzzetta and P. Bonanni and L. Biagi and M. Tosetti and D. Montanaro and R. Guerrini and G. Cioni",
year = "2007",
month = "5",
doi = "10.1016/j.clinph.2007.02.014",
language = "English",
volume = "118",
pages = "1110--1121",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "5",

}

TY - JOUR

T1 - Reorganisation of the somatosensory system after early brain damage

AU - Guzzetta, A.

AU - Bonanni, P.

AU - Biagi, L.

AU - Tosetti, M.

AU - Montanaro, D.

AU - Guerrini, R.

AU - Cioni, G.

PY - 2007/5

Y1 - 2007/5

N2 - Objective: To examine the reorganisation of the somatosensory system after early brain lesions. Methods: We studied 12 young patients with congenital hemiplegia. Causative lesions were brain malformations, periventricular injuries and cortico-subcortical lesions. We explored the somatosensory system using evoked potentials, fMRI during sensory stimulation and clinical assessment of sensory function. To correlate sensory and motor function, we also performed transcranial magnetic stimulation, fMRI of hand movement and assessment of motor function by means of Melbourne test. Results: Eleven patients showed a perilesional reorganisation of primary somatosensory function, as expressed by short latency potentials following stimulation of the paretic hand; in a remaining patient, delayed latency responses (N27.1) were only elicited over the ipsilateral undamaged hemisphere. Five of the eleven patients with perilesional somatosensory representation of the affected hand showed contralesional shifting of motor function, thus exhibiting sensory-motor dissociation. Significant correlation was found between sensory deficit and fMRI activation during sensory stimulation. Conclusions: In subjects with early brain lesions, somato-sensory function is generally reorganised within the affected hemisphere. A contralesional shifting is uncommon and poorly efficient in function restoration. Significance: This study confirms and further explores the difference in reorganisation capabilities of the motor and sensory system following early brain injury of different etiologies and timing.

AB - Objective: To examine the reorganisation of the somatosensory system after early brain lesions. Methods: We studied 12 young patients with congenital hemiplegia. Causative lesions were brain malformations, periventricular injuries and cortico-subcortical lesions. We explored the somatosensory system using evoked potentials, fMRI during sensory stimulation and clinical assessment of sensory function. To correlate sensory and motor function, we also performed transcranial magnetic stimulation, fMRI of hand movement and assessment of motor function by means of Melbourne test. Results: Eleven patients showed a perilesional reorganisation of primary somatosensory function, as expressed by short latency potentials following stimulation of the paretic hand; in a remaining patient, delayed latency responses (N27.1) were only elicited over the ipsilateral undamaged hemisphere. Five of the eleven patients with perilesional somatosensory representation of the affected hand showed contralesional shifting of motor function, thus exhibiting sensory-motor dissociation. Significant correlation was found between sensory deficit and fMRI activation during sensory stimulation. Conclusions: In subjects with early brain lesions, somato-sensory function is generally reorganised within the affected hemisphere. A contralesional shifting is uncommon and poorly efficient in function restoration. Significance: This study confirms and further explores the difference in reorganisation capabilities of the motor and sensory system following early brain injury of different etiologies and timing.

KW - fMRI

KW - Melbourne test

KW - Primary sensory cortex

KW - SEPs

KW - Somatosensory system

UR - http://www.scopus.com/inward/record.url?scp=34047176522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047176522&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2007.02.014

DO - 10.1016/j.clinph.2007.02.014

M3 - Article

VL - 118

SP - 1110

EP - 1121

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 5

ER -