Reproducibilidad de la cuantificacion de la sensibilidad a la accion insulinica con el modelo minimo y comparacion con un test de tolerancia a bajas dosis de insulina

Translated title of the contribution: Repeatability of insulin sensitivity estimation using the Minimal and Model and comparison with a modified short low-dose insulin tolerance test

Ricardo H. Rey, Lucas D. Masnatta, Daniel Pirola, Luis A. Cuniberti, Cristina Maceira, Jose P. Werba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hyperinsulinemia and insulin-resistance are metabolic disturbances associated with obesity, essential hypertension, hypertriglyceridemia, glucose intolerance, overt non-insulin dependent diabetes mellitus, polymetabolic syndrome and atherosclerotic disease. The assessment of in vivo insulin sensitivity (SAI in vivo) changes achieved by life style modifications or drug interventions require a reproducible technique. To evaluate the day-to-day intra-individual repeatability of SAI in vivo, we determined the variation in the SlIindex (calculated from the Minimal Model of Bergman modified by insulin or MMins) in 11 subjects with a wide range of insulin-resistance. SI (first study) varied from 0.82 to 8.48 × 10-4 min-1/μU.mL (4.43 ± 2.85 × 10-4 min-1/μU.mLmean ± SD) and highly correlated with SI (second study) (r = 0.89; p = 0.0002). The average interday coefficient of variation was 20.9 ± 13.9% and was similar in subjects with low or high SI values. We also measured SAI in vivo by assessing the rate of serum glucose decline induced by human cristalline insulin 0.025 U/kg IV dose after a 12-14 hours fasting period (a modified Bonora's method or BBD) in 11 subjects. No subject presented biochemical or symptomatic hypoglycemia. SAI in vivo values determined by BBD varied from 21 a 234 μmol/ml/ min (134 ± 64.8 μmol/ml/min, mean ± SD). Wefound a highly significant correlation between SI values obtained from MM/ns and SAI in vivo assesed by the BBD (r = 0.89, p = 0.0002). Our results suggest that the Mmins is a fairly reproducible procedure and that a BBD is an acceptable option to quantify SAI in vivo, mainly when a fast-execution practice is necessary or cost restrictions are required.

Original languageSpanish
Pages (from-to)650-656
Number of pages7
JournalMedicina
Volume56
Issue number6
Publication statusPublished - 1996

Fingerprint

Insulin Resistance
Insulin
Glucose Intolerance
Hypertriglyceridemia
Hyperinsulinism
Hypoglycemia
Type 2 Diabetes Mellitus
Life Style
Fasting
Obesity
Costs and Cost Analysis
Glucose
Serum
Pharmaceutical Preparations
Essential Hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Reproducibilidad de la cuantificacion de la sensibilidad a la accion insulinica con el modelo minimo y comparacion con un test de tolerancia a bajas dosis de insulina. / Rey, Ricardo H.; Masnatta, Lucas D.; Pirola, Daniel; Cuniberti, Luis A.; Maceira, Cristina; Werba, Jose P.

In: Medicina, Vol. 56, No. 6, 1996, p. 650-656.

Research output: Contribution to journalArticle

Rey, Ricardo H. ; Masnatta, Lucas D. ; Pirola, Daniel ; Cuniberti, Luis A. ; Maceira, Cristina ; Werba, Jose P. / Reproducibilidad de la cuantificacion de la sensibilidad a la accion insulinica con el modelo minimo y comparacion con un test de tolerancia a bajas dosis de insulina. In: Medicina. 1996 ; Vol. 56, No. 6. pp. 650-656.
@article{078a97549ebd45598c656ddba4dd039b,
title = "Reproducibilidad de la cuantificacion de la sensibilidad a la accion insulinica con el modelo minimo y comparacion con un test de tolerancia a bajas dosis de insulina",
abstract = "Hyperinsulinemia and insulin-resistance are metabolic disturbances associated with obesity, essential hypertension, hypertriglyceridemia, glucose intolerance, overt non-insulin dependent diabetes mellitus, polymetabolic syndrome and atherosclerotic disease. The assessment of in vivo insulin sensitivity (SAI in vivo) changes achieved by life style modifications or drug interventions require a reproducible technique. To evaluate the day-to-day intra-individual repeatability of SAI in vivo, we determined the variation in the SlIindex (calculated from the Minimal Model of Bergman modified by insulin or MMins) in 11 subjects with a wide range of insulin-resistance. SI (first study) varied from 0.82 to 8.48 × 10-4 min-1/μU.mL (4.43 ± 2.85 × 10-4 min-1/μU.mLmean ± SD) and highly correlated with SI (second study) (r = 0.89; p = 0.0002). The average interday coefficient of variation was 20.9 ± 13.9{\%} and was similar in subjects with low or high SI values. We also measured SAI in vivo by assessing the rate of serum glucose decline induced by human cristalline insulin 0.025 U/kg IV dose after a 12-14 hours fasting period (a modified Bonora's method or BBD) in 11 subjects. No subject presented biochemical or symptomatic hypoglycemia. SAI in vivo values determined by BBD varied from 21 a 234 μmol/ml/ min (134 ± 64.8 μmol/ml/min, mean ± SD). Wefound a highly significant correlation between SI values obtained from MM/ns and SAI in vivo assesed by the BBD (r = 0.89, p = 0.0002). Our results suggest that the Mmins is a fairly reproducible procedure and that a BBD is an acceptable option to quantify SAI in vivo, mainly when a fast-execution practice is necessary or cost restrictions are required.",
author = "Rey, {Ricardo H.} and Masnatta, {Lucas D.} and Daniel Pirola and Cuniberti, {Luis A.} and Cristina Maceira and Werba, {Jose P.}",
year = "1996",
language = "Spagnolo",
volume = "56",
pages = "650--656",
journal = "Medicina",
issn = "0025-7680",
publisher = "Instituto de Investigaciones Medicas",
number = "6",

}

TY - JOUR

T1 - Reproducibilidad de la cuantificacion de la sensibilidad a la accion insulinica con el modelo minimo y comparacion con un test de tolerancia a bajas dosis de insulina

AU - Rey, Ricardo H.

AU - Masnatta, Lucas D.

AU - Pirola, Daniel

AU - Cuniberti, Luis A.

AU - Maceira, Cristina

AU - Werba, Jose P.

PY - 1996

Y1 - 1996

N2 - Hyperinsulinemia and insulin-resistance are metabolic disturbances associated with obesity, essential hypertension, hypertriglyceridemia, glucose intolerance, overt non-insulin dependent diabetes mellitus, polymetabolic syndrome and atherosclerotic disease. The assessment of in vivo insulin sensitivity (SAI in vivo) changes achieved by life style modifications or drug interventions require a reproducible technique. To evaluate the day-to-day intra-individual repeatability of SAI in vivo, we determined the variation in the SlIindex (calculated from the Minimal Model of Bergman modified by insulin or MMins) in 11 subjects with a wide range of insulin-resistance. SI (first study) varied from 0.82 to 8.48 × 10-4 min-1/μU.mL (4.43 ± 2.85 × 10-4 min-1/μU.mLmean ± SD) and highly correlated with SI (second study) (r = 0.89; p = 0.0002). The average interday coefficient of variation was 20.9 ± 13.9% and was similar in subjects with low or high SI values. We also measured SAI in vivo by assessing the rate of serum glucose decline induced by human cristalline insulin 0.025 U/kg IV dose after a 12-14 hours fasting period (a modified Bonora's method or BBD) in 11 subjects. No subject presented biochemical or symptomatic hypoglycemia. SAI in vivo values determined by BBD varied from 21 a 234 μmol/ml/ min (134 ± 64.8 μmol/ml/min, mean ± SD). Wefound a highly significant correlation between SI values obtained from MM/ns and SAI in vivo assesed by the BBD (r = 0.89, p = 0.0002). Our results suggest that the Mmins is a fairly reproducible procedure and that a BBD is an acceptable option to quantify SAI in vivo, mainly when a fast-execution practice is necessary or cost restrictions are required.

AB - Hyperinsulinemia and insulin-resistance are metabolic disturbances associated with obesity, essential hypertension, hypertriglyceridemia, glucose intolerance, overt non-insulin dependent diabetes mellitus, polymetabolic syndrome and atherosclerotic disease. The assessment of in vivo insulin sensitivity (SAI in vivo) changes achieved by life style modifications or drug interventions require a reproducible technique. To evaluate the day-to-day intra-individual repeatability of SAI in vivo, we determined the variation in the SlIindex (calculated from the Minimal Model of Bergman modified by insulin or MMins) in 11 subjects with a wide range of insulin-resistance. SI (first study) varied from 0.82 to 8.48 × 10-4 min-1/μU.mL (4.43 ± 2.85 × 10-4 min-1/μU.mLmean ± SD) and highly correlated with SI (second study) (r = 0.89; p = 0.0002). The average interday coefficient of variation was 20.9 ± 13.9% and was similar in subjects with low or high SI values. We also measured SAI in vivo by assessing the rate of serum glucose decline induced by human cristalline insulin 0.025 U/kg IV dose after a 12-14 hours fasting period (a modified Bonora's method or BBD) in 11 subjects. No subject presented biochemical or symptomatic hypoglycemia. SAI in vivo values determined by BBD varied from 21 a 234 μmol/ml/ min (134 ± 64.8 μmol/ml/min, mean ± SD). Wefound a highly significant correlation between SI values obtained from MM/ns and SAI in vivo assesed by the BBD (r = 0.89, p = 0.0002). Our results suggest that the Mmins is a fairly reproducible procedure and that a BBD is an acceptable option to quantify SAI in vivo, mainly when a fast-execution practice is necessary or cost restrictions are required.

UR - http://www.scopus.com/inward/record.url?scp=0030309107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030309107&partnerID=8YFLogxK

M3 - Articolo

VL - 56

SP - 650

EP - 656

JO - Medicina

JF - Medicina

SN - 0025-7680

IS - 6

ER -