Abstract
Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 85-90 |
| Number of pages | 6 |
| Journal | European Journal of Pharmacology |
| Volume | 176 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 25 1990 |
Keywords
- Adenylate cyclase activity
- Bromocriptine
- Dopamine receptors
- Lisurides
- Neuronal plasticity
- SK&F 82526
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Nisoli, E., Memo, M., Missale, C., Carruba, M. O., & Spano, P. (1990). Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions. European Journal of Pharmacology, 176(1), 85-90. https://doi.org/10.1016/0014-2999(90)90135-S