Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Enzo Nisoli; Maurizio Memo; Cristina Missale; Michele O. Carruba; PierFranco Spano

doi:10.1016/0014-2999(90)90135-S

Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Enzo Nisoli, Maurizio Memo, Cristina Missale, Michele O. Carruba, PierFranco Spano

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	European Journal of Pharmacology
Volume	176
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(90)90135-S
Publication status	Published - Jan 25 1990

Keywords

Adenylate cyclase activity
Bromocriptine
Dopamine receptors
Lisurides
Neuronal plasticity
SK&F 82526

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(90)90135-S

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title = "Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions",

abstract = "Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.",

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author = "Enzo Nisoli and Maurizio Memo and Cristina Missale and Carruba, {Michele O.} and PierFranco Spano",

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AU - Memo, Maurizio

AU - Missale, Cristina

AU - Carruba, Michele O.

AU - Spano, PierFranco

PY - 1990/1/25

Y1 - 1990/1/25

N2 - Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.

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KW - Lisurides

KW - Neuronal plasticity

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Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Abstract

Keywords

ASJC Scopus subject areas

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