Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Enzo Nisoli; Maurizio Memo; Cristina Missale; Michele O. Carruba; PierFranco Spano

doi:10.1016/0014-2999(90)90135-S

Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Enzo Nisoli, Maurizio Memo, Cristina Missale, Michele O. Carruba, PierFranco Spano

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	European Journal of Pharmacology
Volume	176
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(90)90135-S
Publication status	Published - Jan 25 1990

Keywords

Adenylate cyclase activity
Bromocriptine
Dopamine receptors
Lisurides
Neuronal plasticity
SK&F 82526

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions. / Nisoli, Enzo; Memo, Maurizio; Missale, Cristina; Carruba, Michele O.; Spano, PierFranco.

In: European Journal of Pharmacology, Vol. 176, No. 1, 25.01.1990, p. 85-90.

Research output: Contribution to journal › Article › peer-review

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abstract = "Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.",

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AU - Carruba, Michele O.

AU - Spano, PierFranco

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Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Abstract

Keywords

ASJC Scopus subject areas

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