TY - JOUR
T1 - Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions
AU - Nisoli, Enzo
AU - Memo, Maurizio
AU - Missale, Cristina
AU - Carruba, Michele O.
AU - Spano, PierFranco
PY - 1990/1/25
Y1 - 1990/1/25
N2 - Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.
AB - Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.
KW - Adenylate cyclase activity
KW - Bromocriptine
KW - Dopamine receptors
KW - Lisurides
KW - Neuronal plasticity
KW - SK&F 82526
UR - http://www.scopus.com/inward/record.url?scp=0025117395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025117395&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(90)90135-S
DO - 10.1016/0014-2999(90)90135-S
M3 - Article
C2 - 1968845
AN - SCOPUS:0025117395
VL - 176
SP - 85
EP - 90
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -