Repeated administration of lisuride down-regulates dopamine D-2 receptor function in mesostriatal and in mesolimbocortical rat brain regions

Enzo Nisoli, Maurizio Memo, Cristina Missale, Michele O. Carruba, PierFranco Spano

Research output: Contribution to journalArticle

Abstract

Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalEuropean Journal of Pharmacology
Volume176
Issue number1
DOIs
Publication statusPublished - Jan 25 1990

Keywords

  • Adenylate cyclase activity
  • Bromocriptine
  • Dopamine receptors
  • Lisurides
  • Neuronal plasticity
  • SK&F 82526

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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