Repeated biopsy in the detection of prostate cancer

when and how many cores

Vincenzo Scattoni, Andrea Russo, Ettore Di Trapani, Umberto Capitanio, Giovanni La Croce, Francesco Montorsi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

PURPOSE: We performed an analysis of the literature about the optimal prostate biopsy (PBX) scheme in the repeated setting

METHODS: We performed a clinical and critical literature review by searching Medline Database from January 2005 up to January 2014. Electronic searches were limited to the English language. The keywords were: prostate cancer, prostate biopsy, transrectal ultrasound, transperineal prostate biopsy.

RESULTS: The recommended approach in repeated setting is still the extended scheme (EPBx) (12 cores). An approach with more than 12 cores according to the clinical characteristics of the patients may optimize cancer detection. Saturation PBx (> 20 cores) clearly improves cancer detection if clinical suspicion persists after previous negative biopsy. Nevertheless international guidelines do not strongly recommended SPBx in all situations of repeated setting. EPBx or SPBX may be, in the future, substituted by multiparametric MRI-targeted biopsies.

CONCLUSIONS: Since the scenario in which a PBx is changing, the issue about the number and location of the cores in PBx is still a matter of debate in repeated setting. At present, EPBx are still the gold standard even if SPBx seems to be necessary in many cases. However, random PBx does not represent the approach of the future, but rather imaging targeted biopsy.

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Prostatic Neoplasms
Biopsy
Prostate
Neoplasms
Language
Databases
Guidelines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Repeated biopsy in the detection of prostate cancer: when and how many cores",
abstract = "PURPOSE: We performed an analysis of the literature about the optimal prostate biopsy (PBX) scheme in the repeated settingMETHODS: We performed a clinical and critical literature review by searching Medline Database from January 2005 up to January 2014. Electronic searches were limited to the English language. The keywords were: prostate cancer, prostate biopsy, transrectal ultrasound, transperineal prostate biopsy.RESULTS: The recommended approach in repeated setting is still the extended scheme (EPBx) (12 cores). An approach with more than 12 cores according to the clinical characteristics of the patients may optimize cancer detection. Saturation PBx (> 20 cores) clearly improves cancer detection if clinical suspicion persists after previous negative biopsy. Nevertheless international guidelines do not strongly recommended SPBx in all situations of repeated setting. EPBx or SPBX may be, in the future, substituted by multiparametric MRI-targeted biopsies.CONCLUSIONS: Since the scenario in which a PBx is changing, the issue about the number and location of the cores in PBx is still a matter of debate in repeated setting. At present, EPBx are still the gold standard even if SPBx seems to be necessary in many cases. However, random PBx does not represent the approach of the future, but rather imaging targeted biopsy.",
author = "Vincenzo Scattoni and Andrea Russo and {Di Trapani}, Ettore and Umberto Capitanio and {La Croce}, Giovanni and Francesco Montorsi",
year = "2014",
month = "12",
day = "1",
doi = "10.4081/aiua.2014.4.311",
language = "English",
volume = "86",
pages = "311--313",
journal = "Archivio Italiano di Urologia Nefrologia Andrologia",
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TY - JOUR

T1 - Repeated biopsy in the detection of prostate cancer

T2 - when and how many cores

AU - Scattoni, Vincenzo

AU - Russo, Andrea

AU - Di Trapani, Ettore

AU - Capitanio, Umberto

AU - La Croce, Giovanni

AU - Montorsi, Francesco

PY - 2014/12/1

Y1 - 2014/12/1

N2 - PURPOSE: We performed an analysis of the literature about the optimal prostate biopsy (PBX) scheme in the repeated settingMETHODS: We performed a clinical and critical literature review by searching Medline Database from January 2005 up to January 2014. Electronic searches were limited to the English language. The keywords were: prostate cancer, prostate biopsy, transrectal ultrasound, transperineal prostate biopsy.RESULTS: The recommended approach in repeated setting is still the extended scheme (EPBx) (12 cores). An approach with more than 12 cores according to the clinical characteristics of the patients may optimize cancer detection. Saturation PBx (> 20 cores) clearly improves cancer detection if clinical suspicion persists after previous negative biopsy. Nevertheless international guidelines do not strongly recommended SPBx in all situations of repeated setting. EPBx or SPBX may be, in the future, substituted by multiparametric MRI-targeted biopsies.CONCLUSIONS: Since the scenario in which a PBx is changing, the issue about the number and location of the cores in PBx is still a matter of debate in repeated setting. At present, EPBx are still the gold standard even if SPBx seems to be necessary in many cases. However, random PBx does not represent the approach of the future, but rather imaging targeted biopsy.

AB - PURPOSE: We performed an analysis of the literature about the optimal prostate biopsy (PBX) scheme in the repeated settingMETHODS: We performed a clinical and critical literature review by searching Medline Database from January 2005 up to January 2014. Electronic searches were limited to the English language. The keywords were: prostate cancer, prostate biopsy, transrectal ultrasound, transperineal prostate biopsy.RESULTS: The recommended approach in repeated setting is still the extended scheme (EPBx) (12 cores). An approach with more than 12 cores according to the clinical characteristics of the patients may optimize cancer detection. Saturation PBx (> 20 cores) clearly improves cancer detection if clinical suspicion persists after previous negative biopsy. Nevertheless international guidelines do not strongly recommended SPBx in all situations of repeated setting. EPBx or SPBX may be, in the future, substituted by multiparametric MRI-targeted biopsies.CONCLUSIONS: Since the scenario in which a PBx is changing, the issue about the number and location of the cores in PBx is still a matter of debate in repeated setting. At present, EPBx are still the gold standard even if SPBx seems to be necessary in many cases. However, random PBx does not represent the approach of the future, but rather imaging targeted biopsy.

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