Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex

Giuseppe Clementi, Antonella Favit, Roberto Curreri, Ferdinando Nicoletti, Umberto Scapagnini

Research output: Contribution to journalArticle

Abstract

Stimulation of inositol phospholipid hydrolysis by norepinephrine or 5-hydroxytryptamine was reduced in hippocampal or cortical slices from rats repeatedly injected with (Asu1.7)eel-calcitonin (2.5 IU/kg i.p.). This effect was specific, as the basal or c carbamylcholine-stimulated inositol phospholipi hydrolysis was unchanged in slices from calcitonin-injected animals. The reduced responsiveness to norepinephrine did not reflect a decreased number or affinity of α1-adrenergic recognition sites, suggesting that calcitonin treatment leads to a reduced coupling between α1-adrenoreceptors and phospholipase C.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalBrain Research
Volume478
Issue number1
DOIs
Publication statusPublished - Jan 23 1989

Keywords

  • (Asu)eel-calcitonin
  • Cortex
  • Cyclic adenosine monophosphate
  • Hippocampus
  • Inositol phospholipid
  • Norepinephrine
  • Serotonin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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