Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study

Adriano Chiò, Gabriele Mora, Vincenzo La Bella, Claudia Caponnetto, Gianluigi Mancardi, Mario Sabatelli, Gabriele Siciliano, Vincenzo Silani, Massimo Corbo, Cristina Moglia, Andrea Calvo, Roberto Mutani, Sergio Rutella, Francesca Gualandi, Mario Melazzini, Rosanna Scimè, Mario Petrini, Paola Bondesan, Silvia Garbelli, Stefania MantovaniCaterina Bendotti, Corrado Tarella, Paolo Ghiglione, Paola Omedé, Marco Ulla, Maria Mascolo, Cecilia Carlesi, Pietro Attilio Tonali, Amelia Conte, Marco Luigetti, Dario Alimonti, Francesco Onida, Patrizia Bossolasco, Giorgio Lambertenghi Deliliers, Francesca Valentino

Research output: Contribution to journalArticle

Abstract

Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G-CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS patients entered an open-label, multicenter trial in which four courses of G-CSF and mannitol were administered at 3-month intervals. Levels of G-CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrease in ALSFRS-R score and forced vital capacity was observed. A significant reduction in CSF levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-17 (IL-17) was observed. G-CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP-1 and IL-17 was found, indicating a G-CSF-induced central anti-inflammatory response.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalMuscle and Nerve
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Amyotrophic lateral sclerosis
  • Clinical trial
  • Granulocyte colony-stimulating factor
  • Hematopoietic stem cells
  • Neuroinflammation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

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    Chiò, A., Mora, G., La Bella, V., Caponnetto, C., Mancardi, G., Sabatelli, M., Siciliano, G., Silani, V., Corbo, M., Moglia, C., Calvo, A., Mutani, R., Rutella, S., Gualandi, F., Melazzini, M., Scimè, R., Petrini, M., Bondesan, P., Garbelli, S., ... Valentino, F. (2011). Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study. Muscle and Nerve, 43(2), 189-195. https://doi.org/10.1002/mus.21851