Abstract
Intra-individual variability for serum and urinary hormones has been inadequately considered in previous studies. Therefore, in the planning phase of a prospective study of Hormones and Diet in the Etiology of Breast Cancer (ORDET study), androgen levels have been examined at two different times in 56 women (26 in premenopause and 30 in postmenopause). Hormonal measurements in serum showed a good level of agreement for both premenopause (pre) and postmenopause (post): androstenedione pre r = 0.70 (p <0.0001), post r = 0.77 (p <0.0001); testosterone pre r = 0.73 (p <0.0001), post log values r = 0.74 (p <0.0001). Dihydrotestosterone showed a good level for premenopause only: log values pre r = 0.82 (p <0.0001), post r = 0.41 (p <0.05). Agreement levels in urine were inferior to those of serum: testosterone pre r = 0.53 (p <0.05), post r = 0.41 (p <0.05); androstanediol log values r = 0.46 (p <0.001), post log values r = 0.57 (p <0.05). Correlation between the two measurements improves considering age, parity, time of blood collection and, for urine, the interval of sample collections.
| Original language | English |
|---|---|
| Pages (from-to) | 1055-1061 |
| Number of pages | 7 |
| Journal | Journal of Clinical Epidemiology |
| Volume | 44 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Androgens
- Breast neoplasm
- Menopause
- Prospective study
ASJC Scopus subject areas
- Medicine(all)
- Epidemiology
- Public Health, Environmental and Occupational Health
Cite this
Repeated serum and urinary androgen measurements in premenopausal and postmenopausal women. / Micheli, A.; Muti, P.; Pisani, P.; Secreto, G.; Recchione, C.; Totis, A.; Fissi, R.; Cavalleri, A.; Panico, S.; Berrino, F.
In: Journal of Clinical Epidemiology, Vol. 44, No. 10, 1991, p. 1055-1061.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Repeated serum and urinary androgen measurements in premenopausal and postmenopausal women
AU - Micheli, A.
AU - Muti, P.
AU - Pisani, P.
AU - Secreto, G.
AU - Recchione, C.
AU - Totis, A.
AU - Fissi, R.
AU - Cavalleri, A.
AU - Panico, S.
AU - Berrino, F.
PY - 1991
Y1 - 1991
N2 - Intra-individual variability for serum and urinary hormones has been inadequately considered in previous studies. Therefore, in the planning phase of a prospective study of Hormones and Diet in the Etiology of Breast Cancer (ORDET study), androgen levels have been examined at two different times in 56 women (26 in premenopause and 30 in postmenopause). Hormonal measurements in serum showed a good level of agreement for both premenopause (pre) and postmenopause (post): androstenedione pre r = 0.70 (p <0.0001), post r = 0.77 (p <0.0001); testosterone pre r = 0.73 (p <0.0001), post log values r = 0.74 (p <0.0001). Dihydrotestosterone showed a good level for premenopause only: log values pre r = 0.82 (p <0.0001), post r = 0.41 (p <0.05). Agreement levels in urine were inferior to those of serum: testosterone pre r = 0.53 (p <0.05), post r = 0.41 (p <0.05); androstanediol log values r = 0.46 (p <0.001), post log values r = 0.57 (p <0.05). Correlation between the two measurements improves considering age, parity, time of blood collection and, for urine, the interval of sample collections.
AB - Intra-individual variability for serum and urinary hormones has been inadequately considered in previous studies. Therefore, in the planning phase of a prospective study of Hormones and Diet in the Etiology of Breast Cancer (ORDET study), androgen levels have been examined at two different times in 56 women (26 in premenopause and 30 in postmenopause). Hormonal measurements in serum showed a good level of agreement for both premenopause (pre) and postmenopause (post): androstenedione pre r = 0.70 (p <0.0001), post r = 0.77 (p <0.0001); testosterone pre r = 0.73 (p <0.0001), post log values r = 0.74 (p <0.0001). Dihydrotestosterone showed a good level for premenopause only: log values pre r = 0.82 (p <0.0001), post r = 0.41 (p <0.05). Agreement levels in urine were inferior to those of serum: testosterone pre r = 0.53 (p <0.05), post r = 0.41 (p <0.05); androstanediol log values r = 0.46 (p <0.001), post log values r = 0.57 (p <0.05). Correlation between the two measurements improves considering age, parity, time of blood collection and, for urine, the interval of sample collections.
KW - Androgens
KW - Breast neoplasm
KW - Menopause
KW - Prospective study
UR - http://www.scopus.com/inward/record.url?scp=0025945440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025945440&partnerID=8YFLogxK
U2 - 10.1016/0895-4356(91)90007-V
DO - 10.1016/0895-4356(91)90007-V
M3 - Article
C2 - 1940998
AN - SCOPUS:0025945440
VL - 44
SP - 1055
EP - 1061
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
IS - 10
ER -