Repeated stressful experiences differently affect brain dopamine receptor subtypes

Stefano Puglisi-Allegra, Eliane Kempf, Carmen Schleef, Simona Cabib

Research output: Contribution to journalArticlepeer-review


The binding of tritiated spiperone (D2 antagonist) and tritiated SCH 23390 (D1 antagonist), in vivo, was investigated in the caudatus putamen (CP) and nucleus accumbens septi (NAS) of mice submitted to ten daily restraint stress sessions. Mice sacrificed 24 hr after the last stressful experience presented a 64% decrease of D2 receptor density (Bmax) but no changes in D1 receptor density in the NAS. In the CP a much smaller (11%) reduction of D2 receptor density was accompanied by a 10% increase of D1 receptors. These results show that the two types of dopamine (DA) receptors adapt in different or even opposite ways to environmental pressure, leading to imbalance between them.

Original languageEnglish
Pages (from-to)1263-1268
Number of pages6
JournalLife Sciences
Issue number13
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pharmacology


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