Repeated stressful experiences differently affect limbic dopamine release during and following stress

Assunta Imperato, Luciano Angelucci, Paola Casolini, Alessandro Zocchi, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

229 Citations (Scopus)

Abstract

The effects of repeated restraint stress exposures (daily 60 min, for 6 days) on extracellular dopamine in the nucleus accumbens, during and after the stress experience, have been investigated in rats by in vivo microdialysis. On the first day, restraint increased dopamine release during the first 40 min followed by a return to basal levels (50-60 min later). As soon as restraint ceased and the rats were set free, there was another increase in dopamine release lasting 40 min. On the second and third day, restraint produced only a slight increase in dopamine release, while no significant changes were evident from the fourth to the sixth day. By contrast, from the second to the sixth day the increase in dopamine release observed once rats were freed, was unchanged in comparison to the first day. The present results show that the activation of the mesolimbic dopaminergic system induced by aversive stimuli adapts to repeated experiences differently from that produced by pleasurable events, suggesting that aversive and rewarding experiences involve different neural systems.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalBrain Research
Volume577
Issue number2
DOIs
Publication statusPublished - Apr 17 1992

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Dopamine
Microdialysis
Nucleus Accumbens

Keywords

  • Adaptive mechanism
  • Chronic restraint stress
  • Dopamine
  • Microdialysis
  • Nucleus accumbens

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Repeated stressful experiences differently affect limbic dopamine release during and following stress. / Imperato, Assunta; Angelucci, Luciano; Casolini, Paola; Zocchi, Alessandro; Puglisi-Allegra, Stefano.

In: Brain Research, Vol. 577, No. 2, 17.04.1992, p. 194-199.

Research output: Contribution to journalArticle

Imperato, Assunta ; Angelucci, Luciano ; Casolini, Paola ; Zocchi, Alessandro ; Puglisi-Allegra, Stefano. / Repeated stressful experiences differently affect limbic dopamine release during and following stress. In: Brain Research. 1992 ; Vol. 577, No. 2. pp. 194-199.
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