Repeated stressful experiences differently affect the time-dependent responses of the mesolimbic dopamine system to the stressor

Assunta Imperato, Simona Cabib, Stefano Puglisi-Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

The increase in mesolimbic dopamine (DA) release observed during the first 40 min of 120 min restraint in naive rats is not evident in repeatedly stressed animals (daily 60 min restraint, for 5 days). However, repeatedly stressed rats show a significant decrease in DA release from 80 min of restraint onwards which is not observable in naive rats. These results indicate that repeated stressful experiences do not produce habituation but alter the response of mesolimbic DA system to the stressor. Moreover, they point to a possible neuronal mechanism underlying stress-induced depression.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalBrain Research
Volume601
Issue number1-2
DOIs
Publication statusPublished - Jan 22 1993

Keywords

  • Depression
  • Habituation
  • Microdialysis
  • Nucleus accumbens
  • Rat
  • Restraint

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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