Repeated transcranial direct current stimulation in prolonged disorders of consciousness: A double-blind cross-over study

Anna Estraneo, Angelo Pascarella, Pasquale Moretta, Orsola Masotta, Salvatore Fiorenza, Grazia Chirico, Emanuela Crispino, Vincenzo Loreto, Luigi Trojano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate effects of 5 sessions of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex in patients with prolonged disorders of consciousness (DOC).

METHODS: Seven patients in vegetative state (VS) and 6 in minimally conscious state (MCS), at ≥3months after brain injury, were randomized into two groups: group 1 received one week of active tDCS and 1week of sham stimulation, separated by 1 resting week; group 2 received active and sham stimulation in reverse order. We performed clinical and EEG evaluations before and after the first stimulation session, two hours after the last weekly stimulation, twice during the resting week, and during a 3-month follow-up.

RESULTS: We observed small changes of patients' conditions after the first tDCS session and immediately after the 5 active stimulations. Substantial clinical and EEG changes were observed in 5/13 patients (3 in MCS and 2 in VS) starting after entire (active and sham) stimulation protocol and further progressing during the next months. No baseline features distinguished patients who improved from patients who did not improve.

CONCLUSIONS: Repeated tDCS did not exert remarkable short-term clinical and EEG effects in patients with prolonged DOC. Further studies should ascertain whether tDCS might promote clinical recovery in the long-term period.

Original languageEnglish
Pages (from-to)464-470
Number of pages7
JournalJournal of the Neurological Sciences
Volume375
DOIs
Publication statusPublished - Apr 15 2017

Fingerprint

Consciousness Disorders
Cross-Over Studies
Persistent Vegetative State
Electroencephalography
Transcranial Direct Current Stimulation
Prefrontal Cortex
Brain Injuries

Keywords

  • Journal Article

Cite this

Repeated transcranial direct current stimulation in prolonged disorders of consciousness : A double-blind cross-over study. / Estraneo, Anna; Pascarella, Angelo; Moretta, Pasquale; Masotta, Orsola; Fiorenza, Salvatore; Chirico, Grazia; Crispino, Emanuela; Loreto, Vincenzo; Trojano, Luigi.

In: Journal of the Neurological Sciences, Vol. 375, 15.04.2017, p. 464-470.

Research output: Contribution to journalArticle

Estraneo, Anna ; Pascarella, Angelo ; Moretta, Pasquale ; Masotta, Orsola ; Fiorenza, Salvatore ; Chirico, Grazia ; Crispino, Emanuela ; Loreto, Vincenzo ; Trojano, Luigi. / Repeated transcranial direct current stimulation in prolonged disorders of consciousness : A double-blind cross-over study. In: Journal of the Neurological Sciences. 2017 ; Vol. 375. pp. 464-470.
@article{fae07eb624b04a38b3dee58447441dc2,
title = "Repeated transcranial direct current stimulation in prolonged disorders of consciousness: A double-blind cross-over study",
abstract = "OBJECTIVE: To evaluate effects of 5 sessions of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex in patients with prolonged disorders of consciousness (DOC).METHODS: Seven patients in vegetative state (VS) and 6 in minimally conscious state (MCS), at ≥3months after brain injury, were randomized into two groups: group 1 received one week of active tDCS and 1week of sham stimulation, separated by 1 resting week; group 2 received active and sham stimulation in reverse order. We performed clinical and EEG evaluations before and after the first stimulation session, two hours after the last weekly stimulation, twice during the resting week, and during a 3-month follow-up.RESULTS: We observed small changes of patients' conditions after the first tDCS session and immediately after the 5 active stimulations. Substantial clinical and EEG changes were observed in 5/13 patients (3 in MCS and 2 in VS) starting after entire (active and sham) stimulation protocol and further progressing during the next months. No baseline features distinguished patients who improved from patients who did not improve.CONCLUSIONS: Repeated tDCS did not exert remarkable short-term clinical and EEG effects in patients with prolonged DOC. Further studies should ascertain whether tDCS might promote clinical recovery in the long-term period.",
keywords = "Journal Article",
author = "Anna Estraneo and Angelo Pascarella and Pasquale Moretta and Orsola Masotta and Salvatore Fiorenza and Grazia Chirico and Emanuela Crispino and Vincenzo Loreto and Luigi Trojano",
note = "Copyright {\circledC} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = "4",
day = "15",
doi = "10.1016/j.jns.2017.02.036",
language = "English",
volume = "375",
pages = "464--470",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Repeated transcranial direct current stimulation in prolonged disorders of consciousness

T2 - A double-blind cross-over study

AU - Estraneo, Anna

AU - Pascarella, Angelo

AU - Moretta, Pasquale

AU - Masotta, Orsola

AU - Fiorenza, Salvatore

AU - Chirico, Grazia

AU - Crispino, Emanuela

AU - Loreto, Vincenzo

AU - Trojano, Luigi

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/4/15

Y1 - 2017/4/15

N2 - OBJECTIVE: To evaluate effects of 5 sessions of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex in patients with prolonged disorders of consciousness (DOC).METHODS: Seven patients in vegetative state (VS) and 6 in minimally conscious state (MCS), at ≥3months after brain injury, were randomized into two groups: group 1 received one week of active tDCS and 1week of sham stimulation, separated by 1 resting week; group 2 received active and sham stimulation in reverse order. We performed clinical and EEG evaluations before and after the first stimulation session, two hours after the last weekly stimulation, twice during the resting week, and during a 3-month follow-up.RESULTS: We observed small changes of patients' conditions after the first tDCS session and immediately after the 5 active stimulations. Substantial clinical and EEG changes were observed in 5/13 patients (3 in MCS and 2 in VS) starting after entire (active and sham) stimulation protocol and further progressing during the next months. No baseline features distinguished patients who improved from patients who did not improve.CONCLUSIONS: Repeated tDCS did not exert remarkable short-term clinical and EEG effects in patients with prolonged DOC. Further studies should ascertain whether tDCS might promote clinical recovery in the long-term period.

AB - OBJECTIVE: To evaluate effects of 5 sessions of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex in patients with prolonged disorders of consciousness (DOC).METHODS: Seven patients in vegetative state (VS) and 6 in minimally conscious state (MCS), at ≥3months after brain injury, were randomized into two groups: group 1 received one week of active tDCS and 1week of sham stimulation, separated by 1 resting week; group 2 received active and sham stimulation in reverse order. We performed clinical and EEG evaluations before and after the first stimulation session, two hours after the last weekly stimulation, twice during the resting week, and during a 3-month follow-up.RESULTS: We observed small changes of patients' conditions after the first tDCS session and immediately after the 5 active stimulations. Substantial clinical and EEG changes were observed in 5/13 patients (3 in MCS and 2 in VS) starting after entire (active and sham) stimulation protocol and further progressing during the next months. No baseline features distinguished patients who improved from patients who did not improve.CONCLUSIONS: Repeated tDCS did not exert remarkable short-term clinical and EEG effects in patients with prolonged DOC. Further studies should ascertain whether tDCS might promote clinical recovery in the long-term period.

KW - Journal Article

U2 - 10.1016/j.jns.2017.02.036

DO - 10.1016/j.jns.2017.02.036

M3 - Article

C2 - 28320187

VL - 375

SP - 464

EP - 470

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -