Repeated treatment with d-fenfluramine or metergoline alters cortex binding of 3H-serotonin and serotonergic sensitivity in rats

Rosario Samanin, Tiziana Mennini, Alessandro Ferraris, Caterina Bendotti, Franco Borsini

Research output: Contribution to journalArticlepeer-review

Abstract

28-day treatment with d-fenfluramine, a serotonin (5HT) releaser and uptake inhibitor, caused significant reduction (23%) of 3H-5HT binding sites (Bmax) in the rat cortex. These sites were significantly increased (31%) in cortical membranes of rats which had received metergoline, a potent serotonin antagonist, for 28 days. Parallel changes were found in the anorectic activity of metachlorophenylpiperazine (m-CPP), a potent central 5HT agonist: chronic treatment with d-fenfluramine or metergoline caused respectively a decrease and in the effect of m-CPP on food intake. The data show that changes in 5HT central receptor number and sensitivity may occur after chronic treatment with drugs acting on brain serotonin.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalEuropean Journal of Pharmacology
Volume61
Issue number2
DOIs
Publication statusPublished - Jan 25 1980

Keywords

  • d-Fenfluramine
  • Food intake
  • m-Chlorophenyl-piperazine
  • Metergoline
  • Serotonin binding

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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