Repetitive myocardial stunning in pigs is associated with the increased expression of inducible and constitutive nitric oxide synthases

Christopher S R Baker, Ornella Rimoldi, Paolo G. Camici, Edward Barnes, Matilde R. Chacon, Tanya Y. Huehns, Dorian O. Haskard, Julia M. Polak, Roger J C Hall

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Nitric oxide (NO) has complex effects on myocardial function particularly following ischaemia-reperfusion. The goal of this study was to examine the result of repetitive myocardial stunning on myocardial NO release and expression of inducible (iNOS) and constitutive (eNOS) NO synthases. Methods and results: Propofol anaesthetised pigs underwent ten, 2-min episodes of circumflex artery occlusion (n=6) or acted as sham operated controls (n=4). Measurements of segment shortening demonstrated a fall in function in the ischaemic territory to 52.5±7.3% (mean±S.E.M.) of baseline shortening 30 min after the stunning stimulus, recovering to 92±8.7% 5.5 h later. Function remained stable in sham controls. The change in venous- arterial [NO] between baseline and 6 h reperfusion was found to be significantly different between the two groups (0.2±0.7 in stunned vs. - 4.3±1.6 μM in shams; P

Original languageEnglish
Pages (from-to)685-697
Number of pages13
JournalCardiovascular Research
Volume43
Issue number3
DOIs
Publication statusPublished - Aug 15 1999

Keywords

  • Nitric oxide
  • Pig
  • Preconditioning
  • Reperfusion injury
  • Stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Repetitive myocardial stunning in pigs is associated with the increased expression of inducible and constitutive nitric oxide synthases'. Together they form a unique fingerprint.

Cite this