Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis

D. Centonze, G. Koch, V. Versace, F. Mori, S. Rossi, L. Brusa, K. Grossi, F. Torelli, C. Prosperetti, A. Cervellino, G. A. Marfia, P. Stanzione, M. G. Marciani, L. Boffa, G. Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS: We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS: A single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation. CONCLUSIONS: Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis.

Original languageEnglish
Pages (from-to)1045-1050
Number of pages6
JournalNeurology
Volume68
Issue number13
DOIs
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis'. Together they form a unique fingerprint.

Cite this