Replacement therapy and cardiovascular diseases.

M. Boschetti, U. Goglia, C. Teti, D. Esposito, M. Giusti, F. Minuto, D. Ferone

Research output: Contribution to journalArticle

Abstract

It is known that hypopituitarism reduces life expectancy and increases the risk of death for cardio- and cerebrovascular disease. Many studies report this phenomenon due to vascular diseases, and GH deficiency (GHD) seems to significantly contribute to the higher mortality. Aim of this article is to review the relationship between GH and cardiovascular risk factors to evaluate the beneficial effects of therapy in the adult GHD. GH replacement therapy (GHRT) improves insulin sensitivity, and reduces LDL cholesterol and triglyceride levels. Several studies also documented a decrease in the intima-media thickness at major arteries and improvement in microvascular and endothelial function. Other studies showed a decrease of inflammatory markers and the normalization of coagulation parameters. Finally, some authors have reported improvements in cardiac performance as well. These data evidence the positive effects of GHRT in the prevention of premature atherosclerosis in adults with GHD, and encourage the early administration of replacement therapy.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalJournal of Endocrinological Investigation
Volume31
Issue number9 Suppl
Publication statusPublished - Sep 2008

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Cardiovascular Diseases
Cerebrovascular Disorders
Hypopituitarism
Therapeutics
Life Expectancy
Vascular Diseases
LDL Cholesterol
Insulin Resistance
Atherosclerosis
Arteries
Mortality

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Boschetti, M., Goglia, U., Teti, C., Esposito, D., Giusti, M., Minuto, F., & Ferone, D. (2008). Replacement therapy and cardiovascular diseases. Journal of Endocrinological Investigation, 31(9 Suppl), 85-90.

Replacement therapy and cardiovascular diseases. / Boschetti, M.; Goglia, U.; Teti, C.; Esposito, D.; Giusti, M.; Minuto, F.; Ferone, D.

In: Journal of Endocrinological Investigation, Vol. 31, No. 9 Suppl, 09.2008, p. 85-90.

Research output: Contribution to journalArticle

Boschetti, M, Goglia, U, Teti, C, Esposito, D, Giusti, M, Minuto, F & Ferone, D 2008, 'Replacement therapy and cardiovascular diseases.', Journal of Endocrinological Investigation, vol. 31, no. 9 Suppl, pp. 85-90.
Boschetti M, Goglia U, Teti C, Esposito D, Giusti M, Minuto F et al. Replacement therapy and cardiovascular diseases. Journal of Endocrinological Investigation. 2008 Sep;31(9 Suppl):85-90.
Boschetti, M. ; Goglia, U. ; Teti, C. ; Esposito, D. ; Giusti, M. ; Minuto, F. ; Ferone, D. / Replacement therapy and cardiovascular diseases. In: Journal of Endocrinological Investigation. 2008 ; Vol. 31, No. 9 Suppl. pp. 85-90.
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