Replication studies in longevity: Puzzling findings in Danish centenarians at the 3′ APOB-VNTR locus

O. Varcasia, S. Garasto, T. Rizza, K. Andersen-Ranberg, B. Jeune, L. Bathum, K. Andreev, Q. Tan, A. I. Yashin, M. Bonafè, C. Franceschi, G. De Benedictis

Research output: Contribution to journalArticle

Abstract

In Danes we replicated the 3′ APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalAnnals of Human Genetics
Volume65
Issue number4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Varcasia, O., Garasto, S., Rizza, T., Andersen-Ranberg, K., Jeune, B., Bathum, L., Andreev, K., Tan, Q., Yashin, A. I., Bonafè, M., Franceschi, C., & De Benedictis, G. (2001). Replication studies in longevity: Puzzling findings in Danish centenarians at the 3′ APOB-VNTR locus. Annals of Human Genetics, 65(4), 371-376. https://doi.org/10.1017/S0003480001008715