TY - JOUR
T1 - Replication studies in longevity
T2 - Puzzling findings in Danish centenarians at the 3′ APOB-VNTR locus
AU - Varcasia, O.
AU - Garasto, S.
AU - Rizza, T.
AU - Andersen-Ranberg, K.
AU - Jeune, B.
AU - Bathum, L.
AU - Andreev, K.
AU - Tan, Q.
AU - Yashin, A. I.
AU - Bonafè, M.
AU - Franceschi, C.
AU - De Benedictis, G.
PY - 2001
Y1 - 2001
N2 - In Danes we replicated the 3′ APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.
AB - In Danes we replicated the 3′ APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.
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U2 - 10.1017/S0003480001008715
DO - 10.1017/S0003480001008715
M3 - Article
C2 - 11592926
AN - SCOPUS:0034794196
VL - 65
SP - 371
EP - 376
JO - Annals of Human Genetics
JF - Annals of Human Genetics
SN - 0003-4800
IS - 4
ER -