TY - JOUR
T1 - Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in alzheimer's disease patients
AU - Albani, Diego
AU - Boneschi, Filippo Martinelli
AU - Biella, Gloria
AU - Giacalone, Giacomo
AU - Lupoli, Sara
AU - Clerici, Francesca
AU - Benussi, Luisa
AU - Ghidoni, Roberta
AU - Galimberti, Daniela
AU - Squitti, Rosanna
AU - Mariani, Stefania
AU - Confaloni, Annamaria
AU - Bruno, Giuseppe
AU - Mariani, Claudio
AU - Scarpini, Elio
AU - Binetti, Giuliano
AU - Magnani, Giuseppe
AU - Franceschi, Massimo
AU - Forloni, Gianluigi
PY - 2012
Y1 - 2012
N2 - Alzheimer's disease (AD) is a neurodegenerative disorder often treated with donepezil, an acetylcholinesterase inhibitor. Response to donepezil is variable, probably based on patients' genetic background in donepezil metabolizing enzymes, including cytochrome 2D6 (CYP2D6). We evaluated the association between clinical response to donepezil and a common variant (rs1080985) of CYP2D6, previously reported to be associated with poor response to the drug. In a sample of 415 AD cases, we found evidence of association between rs1080985 and response to donepezil after 6 months of therapy (OR [95% CI]: 1.74 [1.01-3.00], p = 0.04). Rs1080985 might be useful as predictor of poor response to short-term donepezil treatment.
AB - Alzheimer's disease (AD) is a neurodegenerative disorder often treated with donepezil, an acetylcholinesterase inhibitor. Response to donepezil is variable, probably based on patients' genetic background in donepezil metabolizing enzymes, including cytochrome 2D6 (CYP2D6). We evaluated the association between clinical response to donepezil and a common variant (rs1080985) of CYP2D6, previously reported to be associated with poor response to the drug. In a sample of 415 AD cases, we found evidence of association between rs1080985 and response to donepezil after 6 months of therapy (OR [95% CI]: 1.74 [1.01-3.00], p = 0.04). Rs1080985 might be useful as predictor of poor response to short-term donepezil treatment.
KW - Alzheimer's disease
KW - apolipoprotein E
KW - CYP2D6
KW - donepezil
KW - pharmacogenetics
KW - rs1080985
UR - http://www.scopus.com/inward/record.url?scp=84862982197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862982197&partnerID=8YFLogxK
U2 - 10.3233/JAD-2012-112123
DO - 10.3233/JAD-2012-112123
M3 - Article
C2 - 22465999
AN - SCOPUS:84862982197
VL - 30
SP - 745
EP - 749
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -