Report of an unusual small lymphocytic B-cell lymphoma selectively involving the B-zone of lymph node

A. Carbone, A. Pinto, A. Gloghini, V. De Re, M. Alosi, V. Zagonel, U. Tirelli, V. Attadia, M. Boiocchi, R. Volpe

Research output: Contribution to journalArticle

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Abstract

Selective involvement of the B-cell compartment of lymph node by B-cell malignant lymphomas is an occasional finding related to early phases of lymph node infiltration. The authors have observed a unique case of diffuse small lymphocytic lymphoma that consisted of immunohistologically and genotypically proven B-clonal population exhibiting a repetitive pattern of infiltration in three lymph node samples obtained from the patient during a 9-year period. This pattern consisted of a selective and complete replacement of the B-areas with disappearance of follicles and widening of the medullary cords, an expanded T-zone showing features consistent with dermatopathic lymphadenitis and well-preserved sinuses. Clinically, multiple involved sites at presentation (lymph nodes, spleen, skin, bone marrow, and peripheral blood) and during the 9-year follow-up (testis) were detected, and the disease was associated with a relative indolent course like other low-grade lymphomas. The phenotypic profile of lymphoma cells studied by immunoperoxidase method, and by single-labeling and double-labeling flow cytometric analyses (SIg+, K+, LN2+, MB1+, MB2+, HLA-DR+, CD9+, CD20+, CD21+, CD22+, CD24+, Leu8+, CD5-, CD10-, CD11b-, CD11c-, CD25-, CD38-, PCA-1-, FMC-7, CD23-) was consistent with a B-cell proliferation at an intermediate stage of differentiation but distinct from other well-defined B-cell neoplasms. Whether such unique B-zone pattern was due to an intrinsic property of this lymphoma or it is to be related to the coexisting reactive T-zone expansion remains controversial.

Original languageEnglish
Pages (from-to)302-312
Number of pages11
JournalCancer
Volume66
Issue number2
DOIs
Publication statusPublished - 1990

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B-Cell Lymphoma
Lymph Nodes
Lymphoma
B-Lymphocytes
Lymphadenitis
Passive Cutaneous Anaphylaxis
HLA-DR Antigens
B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Testis
Spleen
Bone Marrow
Cell Proliferation
Skin
Population
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Report of an unusual small lymphocytic B-cell lymphoma selectively involving the B-zone of lymph node. / Carbone, A.; Pinto, A.; Gloghini, A.; De Re, V.; Alosi, M.; Zagonel, V.; Tirelli, U.; Attadia, V.; Boiocchi, M.; Volpe, R.

In: Cancer, Vol. 66, No. 2, 1990, p. 302-312.

Research output: Contribution to journalArticle

Carbone, A. ; Pinto, A. ; Gloghini, A. ; De Re, V. ; Alosi, M. ; Zagonel, V. ; Tirelli, U. ; Attadia, V. ; Boiocchi, M. ; Volpe, R. / Report of an unusual small lymphocytic B-cell lymphoma selectively involving the B-zone of lymph node. In: Cancer. 1990 ; Vol. 66, No. 2. pp. 302-312.
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AU - Alosi, M.

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