Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo

Antonello Silvestri, Pasquale Galetta, Elena Cerquetani, Giuseppe Marazzi, Roberto Patrizi, Massimo Fini, G. M C Rosano

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Aims. Patients with cardiovascular diseases frequently complain of erectile dysfunction especially when treated with beta-blockers. In order to assess whether the effect of beta-blockers on erectile dysfunction is in part related to patient knowledge of the drug side effects, 96 patients (all males, age 52±7 years) with newly diagnosed cardiovascular disease and not suffering from erectile dysfunction entered a two phase, single cross over study. Methods and results. During the first phase of the study patients received atenolol 50 mg o.d. (A), 32 patients were blinded on the drug given (group A), 32 were informed on the drug given but not on its side effects (group B) and 32 took A after being informed on its side effects on erectile function (group C). After 3 months the incidence of erectile dysfunction was 3.1% in the group A, 15.6% in group B and 31.2% in group C (P

Original languageEnglish
Pages (from-to)1928-1932
Number of pages5
JournalEuropean Heart Journal
Volume24
Issue number21
DOIs
Publication statusPublished - Nov 2003

Fingerprint

Erectile Dysfunction
Placebos
Cardiovascular Diseases
Therapeutics
Atenolol
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Cross-Over Studies
Incidence

Keywords

  • Beta-blockers
  • Cardiovascular disease
  • Erectile dysfunction
  • Sildenafil

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. / Silvestri, Antonello; Galetta, Pasquale; Cerquetani, Elena; Marazzi, Giuseppe; Patrizi, Roberto; Fini, Massimo; Rosano, G. M C.

In: European Heart Journal, Vol. 24, No. 21, 11.2003, p. 1928-1932.

Research output: Contribution to journalArticle

@article{de21e20974ba4c33a4b82f57f4ab1666,
title = "Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo",
abstract = "Aims. Patients with cardiovascular diseases frequently complain of erectile dysfunction especially when treated with beta-blockers. In order to assess whether the effect of beta-blockers on erectile dysfunction is in part related to patient knowledge of the drug side effects, 96 patients (all males, age 52±7 years) with newly diagnosed cardiovascular disease and not suffering from erectile dysfunction entered a two phase, single cross over study. Methods and results. During the first phase of the study patients received atenolol 50 mg o.d. (A), 32 patients were blinded on the drug given (group A), 32 were informed on the drug given but not on its side effects (group B) and 32 took A after being informed on its side effects on erectile function (group C). After 3 months the incidence of erectile dysfunction was 3.1{\%} in the group A, 15.6{\%} in group B and 31.2{\%} in group C (P",
keywords = "Beta-blockers, Cardiovascular disease, Erectile dysfunction, Sildenafil",
author = "Antonello Silvestri and Pasquale Galetta and Elena Cerquetani and Giuseppe Marazzi and Roberto Patrizi and Massimo Fini and Rosano, {G. M C}",
year = "2003",
month = "11",
doi = "10.1016/j.ehj.2003.08.016",
language = "English",
volume = "24",
pages = "1928--1932",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "21",

}

TY - JOUR

T1 - Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo

AU - Silvestri, Antonello

AU - Galetta, Pasquale

AU - Cerquetani, Elena

AU - Marazzi, Giuseppe

AU - Patrizi, Roberto

AU - Fini, Massimo

AU - Rosano, G. M C

PY - 2003/11

Y1 - 2003/11

N2 - Aims. Patients with cardiovascular diseases frequently complain of erectile dysfunction especially when treated with beta-blockers. In order to assess whether the effect of beta-blockers on erectile dysfunction is in part related to patient knowledge of the drug side effects, 96 patients (all males, age 52±7 years) with newly diagnosed cardiovascular disease and not suffering from erectile dysfunction entered a two phase, single cross over study. Methods and results. During the first phase of the study patients received atenolol 50 mg o.d. (A), 32 patients were blinded on the drug given (group A), 32 were informed on the drug given but not on its side effects (group B) and 32 took A after being informed on its side effects on erectile function (group C). After 3 months the incidence of erectile dysfunction was 3.1% in the group A, 15.6% in group B and 31.2% in group C (P

AB - Aims. Patients with cardiovascular diseases frequently complain of erectile dysfunction especially when treated with beta-blockers. In order to assess whether the effect of beta-blockers on erectile dysfunction is in part related to patient knowledge of the drug side effects, 96 patients (all males, age 52±7 years) with newly diagnosed cardiovascular disease and not suffering from erectile dysfunction entered a two phase, single cross over study. Methods and results. During the first phase of the study patients received atenolol 50 mg o.d. (A), 32 patients were blinded on the drug given (group A), 32 were informed on the drug given but not on its side effects (group B) and 32 took A after being informed on its side effects on erectile function (group C). After 3 months the incidence of erectile dysfunction was 3.1% in the group A, 15.6% in group B and 31.2% in group C (P

KW - Beta-blockers

KW - Cardiovascular disease

KW - Erectile dysfunction

KW - Sildenafil

UR - http://www.scopus.com/inward/record.url?scp=0142209279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142209279&partnerID=8YFLogxK

U2 - 10.1016/j.ehj.2003.08.016

DO - 10.1016/j.ehj.2003.08.016

M3 - Article

C2 - 14585251

AN - SCOPUS:0142209279

VL - 24

SP - 1928

EP - 1932

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 21

ER -