Report of ten years' activity in an Alzheimer's disease assessment unit

Elena Sinforiani, Chiara Zucchella, Chiara Pasotti, Michelangelo Bartolo, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review


Background and aims: After ten years' treatment with Cholinesterase inhibitors (AcheI) in Alzheimer's disease (AD), we report here the activity of the Alzheimer's Disease Assessment Unit of IRCCS C. Mondino, Pavia, Italy. Methods: From September 2000 to December 2007, 794 out-patients (of 2236 referred to our Assessment Unit for cognitive disturbances) with AD of mild to moderate degree were treated with Cholinesterase inhibitors (M/F: 273/521, mean age 73.6±8.4 yrs, range 52-85 yrs). Outcome measures were scores on Mini Mental State Examination (MMSE), ADL, IADL and Neuropsychiatric Inventory (NPl). Results: Mean treatment duration was 36.9±16.1 months. After three months' treatment, MMSE scores remained stable (responders) in 60% of cases and improved (increase of 3 or more points - good responders) in 15%, with good preservation of autonomy. After 15 months, the percentage of "good responders" decreased to 7%, while after 15, 27 and 39 months the percentage of responders progressively decreased to 40%, 30% and 8%, respectively; greater impairment in instrumental with respect to basic everyday activities was noted. No variables capable of predicting the response to treatment were detected. The onset of behavioral disturbances caused significant (p

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalAging clinical and experimental research
Issue number4-5
Publication statusPublished - Aug 2009


  • Alzheimer's disease
  • Cholinesterase inhibitors
  • Clinical management

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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