Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects

Matthieu Allez, Konstantinos Karmiris, Edouard Louis, Gert Van Assche, Shomron Ben-Horin, Amir Klein, Janneke Van der Woude, Filip Baert, Rami Eliakim, Konstantinos Katsanos, Jørn Brynskov, Flavio Steinwurz, Silvio Danese, Severine Vermeire, Jean Luc Teillaud, Marc Lémann, Yehuda Chowers

Research output: Contribution to journalArticle

Abstract

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.

Original languageEnglish
Pages (from-to)355-366
Number of pages12
JournalJournal of Crohn's & colitis
Volume4
Issue number4
DOIs
Publication statusPublished - Oct 2010

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Keywords

  • Anti-TNF therapy
  • Crohn's disease
  • Immunogenicity
  • Inflammatory bowel diseases
  • Pharmacology
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Allez, M., Karmiris, K., Louis, E., Van Assche, G., Ben-Horin, S., Klein, A., Van der Woude, J., Baert, F., Eliakim, R., Katsanos, K., Brynskov, J., Steinwurz, F., Danese, S., Vermeire, S., Teillaud, J. L., Lémann, M., & Chowers, Y. (2010). Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects. Journal of Crohn's & colitis, 4(4), 355-366. https://doi.org/10.1016/j.crohns.2010.04.004