Report on liver cell transplantation using human fetal liver cells

Giada Pietrosi, Cinzia Chinnici

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In an era of organ shortage, human fetuses donated after medically indicated abortion could be considered a potential liver donor for hepatic cell isolation. We investigated transplantation of fetal liver cells as a strategy to support liver functionality in end-stage liver disease. Here, we report our protocol of human fetal liver cells (hFLC) isolation in fetuses from 17 to 22 gestational weeks, and our clinical procedure of hFLC transplantation through the splenic artery.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages283-294
Number of pages12
Volume1506
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1506
ISSN (Print)10643745

Keywords

  • Chronic liver disease
  • Collagenase perfusion
  • Fetal liver
  • Fetal stem cell transplantation
  • Liver cell transplantation
  • Liver progenitors
  • Liver stem cell isolation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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