Report on liver cell transplantation using human fetal liver cells

Giada Pietrosi; Cinzia Chinnici

doi:10.1007/978-1-4939-6506-9_20

Report on liver cell transplantation using human fetal liver cells

Giada Pietrosi, Cinzia Chinnici

ISMETT

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In an era of organ shortage, human fetuses donated after medically indicated abortion could be considered a potential liver donor for hepatic cell isolation. We investigated transplantation of fetal liver cells as a strategy to support liver functionality in end-stage liver disease. Here, we report our protocol of human fetal liver cells (hFLC) isolation in fetuses from 17 to 22 gestational weeks, and our clinical procedure of hFLC transplantation through the splenic artery.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	283-294
Number of pages	12
Volume	1506
DOIs	https://doi.org/10.1007/978-1-4939-6506-9_20
Publication status	Published - 2017

Publication series

Name	Methods in Molecular Biology
Volume	1506
ISSN (Print)	10643745

Keywords

Chronic liver disease
Collagenase perfusion
Fetal liver
Fetal stem cell transplantation
Liver cell transplantation
Liver progenitors
Liver stem cell isolation

ASJC Scopus subject areas

Molecular Biology
Genetics

Access to Document

10.1007/978-1-4939-6506-9_20

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abstract = "In an era of organ shortage, human fetuses donated after medically indicated abortion could be considered a potential liver donor for hepatic cell isolation. We investigated transplantation of fetal liver cells as a strategy to support liver functionality in end-stage liver disease. Here, we report our protocol of human fetal liver cells (hFLC) isolation in fetuses from 17 to 22 gestational weeks, and our clinical procedure of hFLC transplantation through the splenic artery.",

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AU - Chinnici, Cinzia

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KW - Collagenase perfusion

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KW - Fetal stem cell transplantation

KW - Liver cell transplantation

KW - Liver progenitors

KW - Liver stem cell isolation

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