TY - JOUR
T1 - Report
T2 - Workshop on mediastinal grey zone lymphoma
AU - Poppema, Sibrand
AU - Kluiver, Joost L.
AU - Atayar, Cigdem
AU - Van Berg, Anke Den
AU - Rosenwald, Andreas
AU - Hummel, Michael
AU - Lenze, Dido
AU - Lammert, Hetty
AU - Stein, Harald
AU - Joos, Stephan
AU - Barth, Thomas
AU - Dyer, Martin
AU - Lichter, Peter
AU - Klein, Uwe
AU - Cattoretti, Giorgio
AU - Gloghini, Annunziata
AU - Tu, Yuhai
AU - Stolovitzky, Gustavo A.
AU - Califano, Andrea
AU - Carbone, Antonino
AU - Dalla-Favera, Ricardo
AU - Melzner, Ingo
AU - Bucur, Alexandra J.
AU - Bruderlein, Silke
AU - Dorsch, Karola
AU - Hasel, Cornelia
AU - Barth, Thomas F E
AU - Leithäuser, Frank
AU - Möller, Peter
PY - 2005/7
Y1 - 2005/7
N2 - There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms. The first indication was the existence of mediastinal grey zone lymphomas as identified in the 4th International Symposium on HL, with clinical, histological and immunohistochemical features intermediate between cHL and PMBL. Second, both tumor types resemble a cell that is developmentally situated in-between the germinal center reaction and a plasma cell. Third, cHL and PMBL were found to have similar gene expression profiles, including the lack of immunoglobulin expression and low levels of B cell receptor signalling molecules, and the secretion of molecules like the chemokine TARC and the prominent expression of IL-13 receptors. Fourth, both entities were found to have common genomic aberrancies, notably in 2p15 and 9p24, the sites of the REL oncogene and the tyrosine kinase gene JAK2, respectively. Further comparison of both lymphoma types may provide further insight in the pathogenic mechanisms and allow the design of diagnostic algorithms to sort out the small number of so-called mediastinal grey zone lymphomas, that appear to be intermediate between PMBL and cHL.
AB - There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms. The first indication was the existence of mediastinal grey zone lymphomas as identified in the 4th International Symposium on HL, with clinical, histological and immunohistochemical features intermediate between cHL and PMBL. Second, both tumor types resemble a cell that is developmentally situated in-between the germinal center reaction and a plasma cell. Third, cHL and PMBL were found to have similar gene expression profiles, including the lack of immunoglobulin expression and low levels of B cell receptor signalling molecules, and the secretion of molecules like the chemokine TARC and the prominent expression of IL-13 receptors. Fourth, both entities were found to have common genomic aberrancies, notably in 2p15 and 9p24, the sites of the REL oncogene and the tyrosine kinase gene JAK2, respectively. Further comparison of both lymphoma types may provide further insight in the pathogenic mechanisms and allow the design of diagnostic algorithms to sort out the small number of so-called mediastinal grey zone lymphomas, that appear to be intermediate between PMBL and cHL.
KW - Classical hodgkin lymphoma
KW - Gene expression profiling
KW - Mediastinal grey zone lymphoma
KW - Primary mediastinal B cell lymphoma
KW - REL
KW - TARC
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M3 - Article
C2 - 16007868
AN - SCOPUS:21044432825
VL - 75
SP - 45
EP - 52
JO - Scandinavian journal of haematology. Supplementum
JF - Scandinavian journal of haematology. Supplementum
SN - 0902-4506
IS - 66
ER -