Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study

Agnes Berendsen, Aurelia Santoro, Elisa Pini, Elisa Cevenini, Rita Ostan, Barbara Pietruszka, Katarzyna Rolf, Noël Cano, Aurélie Caille, Noëlle Lyon-Belgy, Susan Fairweather-Tait, Edith Feskens, Claudio Franceschi, C. P G M de Groot

Research output: Contribution to journalArticle

Abstract

Background: The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. Methods: The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome. Discussion: The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.

Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalMechanisms of Ageing and Development
Volume136-137
DOIs
Publication statusPublished - 2014

Keywords

  • Ageing
  • Elderly
  • Intervention
  • Nutrition

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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    Berendsen, A., Santoro, A., Pini, E., Cevenini, E., Ostan, R., Pietruszka, B., Rolf, K., Cano, N., Caille, A., Lyon-Belgy, N., Fairweather-Tait, S., Feskens, E., Franceschi, C., & de Groot, C. P. G. M. (2014). Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study. Mechanisms of Ageing and Development, 136-137, 14-21. https://doi.org/10.1016/j.mad.2014.03.001