Abstract
People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after it develops to preventing cardiovascular events before they happen by slowing the progression of atherosclerosis. Because atherogenic lipoproteins play a central causal role in the initiation and progression of atherosclerosis, maintaining optimal lipid levels is necessary to achieve ideal cardiovascular health. This review describes the cumulative effect of lipid-carrying lipoproteins on the risk of cardiovascular disease, estimates the magnitude of the clinical benefit that can be achieved by maintaining optimal lipid levels, identifies the most effective timing for implementing strategies designed to achieve optimal lipid levels, and provides a clinical pathway to help people achieve the lipid levels necessary for ideal cardiovascular health.
| Original language | English |
|---|---|
| Pages (from-to) | 2980-2995 |
| Number of pages | 16 |
| Journal | Journal of the American College of Cardiology |
| Volume | 72 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Dec 11 2018 |
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Keywords
- apolipoproteins
- cholesterol
- low-density lipoproteins
- population
- risk
- total burden
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Reprint of : Impact of Lipids on Cardiovascular Health: JACC Health Promotion Series. / Ference, Brian A.; Graham, Ian; Tokgozoglu, Lale; Catapano, Alberico L.
In: Journal of the American College of Cardiology, Vol. 72, No. 23, 11.12.2018, p. 2980-2995.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Reprint of
T2 - Impact of Lipids on Cardiovascular Health: JACC Health Promotion Series
AU - Ference, Brian A.
AU - Graham, Ian
AU - Tokgozoglu, Lale
AU - Catapano, Alberico L.
PY - 2018/12/11
Y1 - 2018/12/11
N2 - People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after it develops to preventing cardiovascular events before they happen by slowing the progression of atherosclerosis. Because atherogenic lipoproteins play a central causal role in the initiation and progression of atherosclerosis, maintaining optimal lipid levels is necessary to achieve ideal cardiovascular health. This review describes the cumulative effect of lipid-carrying lipoproteins on the risk of cardiovascular disease, estimates the magnitude of the clinical benefit that can be achieved by maintaining optimal lipid levels, identifies the most effective timing for implementing strategies designed to achieve optimal lipid levels, and provides a clinical pathway to help people achieve the lipid levels necessary for ideal cardiovascular health.
AB - People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after it develops to preventing cardiovascular events before they happen by slowing the progression of atherosclerosis. Because atherogenic lipoproteins play a central causal role in the initiation and progression of atherosclerosis, maintaining optimal lipid levels is necessary to achieve ideal cardiovascular health. This review describes the cumulative effect of lipid-carrying lipoproteins on the risk of cardiovascular disease, estimates the magnitude of the clinical benefit that can be achieved by maintaining optimal lipid levels, identifies the most effective timing for implementing strategies designed to achieve optimal lipid levels, and provides a clinical pathway to help people achieve the lipid levels necessary for ideal cardiovascular health.
KW - apolipoproteins
KW - cholesterol
KW - low-density lipoproteins
KW - population
KW - risk
KW - total burden
UR - http://www.scopus.com/inward/record.url?scp=85056839716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056839716&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2018.10.021
DO - 10.1016/j.jacc.2018.10.021
M3 - Review article
C2 - 30522632
AN - SCOPUS:85056839716
VL - 72
SP - 2980
EP - 2995
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 23
ER -