Reprint of: The natural history of adenomas

Mauro Risio

Research output: Contribution to journalArticlepeer-review


It is well known that adenomas represent the morphologically categorised precursor of the vast majority of colorectal cancers. Only few adenomas actually develop invasive cancer (progressive adenomas), although every adenoma has the capacity of malignant evolution. Most adenomas stabilise their progression or even regress. Easily identifiable but widely ranged pathological features (size, architectural growth, type, grade and gross organisation of dysplasia) are predictive of their natural history in terms of potential of cancerisation and duration of the adenoma-carcinoma sequence. Knowledge of the biological machineries sustaining the progression rates and times could be crucial to refine the natural history assumptions in screening modelling.

Original languageEnglish
Pages (from-to)397-406
Number of pages10
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Issue number4
Publication statusPublished - Aug 2010


  • Cancerised adenoma
  • Colorectal adenomas
  • Dysplasia
  • Serrated polyps
  • Tumour progression

ASJC Scopus subject areas

  • Gastroenterology


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