Reproducibility in the diagnosis of needle core biopsies of non-palpable breast lesions: An international study using virtual slides published on the world-wide web

Francesco Alfredo Zito, Paolo Verderio, Giovanni Simone, Vito Angione, Paola Apicella, Simonetta Bianchi, Antonio Felix Conde, Omar Hameed, Julio Ibarra, Antony Leong, Natale Pennelli, Ezio Pezzica, Vania Vezzosi, Vincenzo Ventrella, Sara Pizzamiglio, Angelo Paradiso, Ian Ellis

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To conduct an internet-based study using virtual slides (VS) of sterotactic core biopsy specimens of non-palpable breast lesions in order to evaluate interobserver reproducibility between pathologists. Methods and results: A total of 18 breast lesions, determined to be histologically complex by two pathologists, were selected. Digitized VSs were then created using QuickTime Virtual Reality technology (Apple, Cupertino, CA, USA) and posted on the world-wide web. In all, 10 pathologists completed the evaluations of 18 VSs using the five diagnostic categories (B1-B5) from the European guidelines for quality assurance in breast cancer screening and diagnosis. Their results were compared with those of every other participating pathologist, and were then individually compared with the results of a highly experienced breast pathologist (referee). Of the 18 cases, 10 (56%) were classified by the referee as borderline (B3 and B4). Comparisons with reference values showed a less than satisfactory level of reproducibility (median κw = 0.60). As regards interobserver reproducibility, results showed that, in general, the level of agreement was not satisfactory (median κw = 0.53). Conclusions: Overall, the findings are comparable to those quality control studies using circulating slides when analysis is done on borderline cases.

Original languageEnglish
Pages (from-to)720-726
Number of pages7
JournalHistopathology
Volume56
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • Atypical ductal hyperplasia
  • Core breast biopsy
  • Quality control
  • Telepathology
  • Virtual slide

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Reproducibility in the diagnosis of needle core biopsies of non-palpable breast lesions: An international study using virtual slides published on the world-wide web'. Together they form a unique fingerprint.

Cite this