Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses

Luigi De Gennaro, Michele Ferrara, Mario Bertini, Flavia Pauri, Riccardo Cristiani, Giuseppe Curcio, Vincenzo Romei, Fabiana Fratello, Paolo Maria Rossini

Research output: Contribution to journalArticlepeer-review


Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalNeuroscience Research
Issue number2
Publication statusPublished - Jun 1 2003


  • Inter- and intra-individual variability
  • Motor evoked potentials
  • Paired-pulse technique
  • Reproducibility
  • Transcallosal inhibition
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)


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