Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses

Luigi De Gennaro, Michele Ferrara, Mario Bertini, Flavia Pauri, Riccardo Cristiani, Giuseppe Curcio, Vincenzo Romei, Fabiana Fratello, Paolo Maria Rossini

Research output: Contribution to journalArticle

Abstract

Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalNeuroscience Research
Volume46
Issue number2
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Transcranial Magnetic Stimulation
Corpus Callosum
Motor Cortex
Healthy Volunteers
Hand
Muscles

Keywords

  • Inter- and intra-individual variability
  • Motor evoked potentials
  • Paired-pulse technique
  • Reproducibility
  • Transcallosal inhibition
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses. / De Gennaro, Luigi; Ferrara, Michele; Bertini, Mario; Pauri, Flavia; Cristiani, Riccardo; Curcio, Giuseppe; Romei, Vincenzo; Fratello, Fabiana; Rossini, Paolo Maria.

In: Neuroscience Research, Vol. 46, No. 2, 01.06.2003, p. 219-227.

Research output: Contribution to journalArticle

De Gennaro, L, Ferrara, M, Bertini, M, Pauri, F, Cristiani, R, Curcio, G, Romei, V, Fratello, F & Rossini, PM 2003, 'Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses', Neuroscience Research, vol. 46, no. 2, pp. 219-227. https://doi.org/10.1016/S0168-0102(03)00060-9
De Gennaro, Luigi ; Ferrara, Michele ; Bertini, Mario ; Pauri, Flavia ; Cristiani, Riccardo ; Curcio, Giuseppe ; Romei, Vincenzo ; Fratello, Fabiana ; Rossini, Paolo Maria. / Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses. In: Neuroscience Research. 2003 ; Vol. 46, No. 2. pp. 219-227.
@article{c12eac672f514ce6bb50fe96be5d522e,
title = "Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses",
abstract = "Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.",
keywords = "Inter- and intra-individual variability, Motor evoked potentials, Paired-pulse technique, Reproducibility, Transcallosal inhibition, Transcranial magnetic stimulation",
author = "{De Gennaro}, Luigi and Michele Ferrara and Mario Bertini and Flavia Pauri and Riccardo Cristiani and Giuseppe Curcio and Vincenzo Romei and Fabiana Fratello and Rossini, {Paolo Maria}",
year = "2003",
month = "6",
day = "1",
doi = "10.1016/S0168-0102(03)00060-9",
language = "English",
volume = "46",
pages = "219--227",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses

AU - De Gennaro, Luigi

AU - Ferrara, Michele

AU - Bertini, Mario

AU - Pauri, Flavia

AU - Cristiani, Riccardo

AU - Curcio, Giuseppe

AU - Romei, Vincenzo

AU - Fratello, Fabiana

AU - Rossini, Paolo Maria

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.

AB - Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.

KW - Inter- and intra-individual variability

KW - Motor evoked potentials

KW - Paired-pulse technique

KW - Reproducibility

KW - Transcallosal inhibition

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=0038629122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038629122&partnerID=8YFLogxK

U2 - 10.1016/S0168-0102(03)00060-9

DO - 10.1016/S0168-0102(03)00060-9

M3 - Article

C2 - 12767485

AN - SCOPUS:0038629122

VL - 46

SP - 219

EP - 227

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 2

ER -