Abstract
Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.
| Original language | English |
|---|---|
| Pages (from-to) | 219-227 |
| Number of pages | 9 |
| Journal | Neuroscience Research |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 1 2003 |
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Keywords
- Inter- and intra-individual variability
- Motor evoked potentials
- Paired-pulse technique
- Reproducibility
- Transcallosal inhibition
- Transcranial magnetic stimulation
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses. / De Gennaro, Luigi; Ferrara, Michele; Bertini, Mario; Pauri, Flavia; Cristiani, Riccardo; Curcio, Giuseppe; Romei, Vincenzo; Fratello, Fabiana; Rossini, Paolo Maria.
In: Neuroscience Research, Vol. 46, No. 2, 01.06.2003, p. 219-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses
AU - De Gennaro, Luigi
AU - Ferrara, Michele
AU - Bertini, Mario
AU - Pauri, Flavia
AU - Cristiani, Riccardo
AU - Curcio, Giuseppe
AU - Romei, Vincenzo
AU - Fratello, Fabiana
AU - Rossini, Paolo Maria
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.
AB - Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test-retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.
KW - Inter- and intra-individual variability
KW - Motor evoked potentials
KW - Paired-pulse technique
KW - Reproducibility
KW - Transcallosal inhibition
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=0038629122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038629122&partnerID=8YFLogxK
U2 - 10.1016/S0168-0102(03)00060-9
DO - 10.1016/S0168-0102(03)00060-9
M3 - Article
C2 - 12767485
AN - SCOPUS:0038629122
VL - 46
SP - 219
EP - 227
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 2
ER -