Abstract
Blood oxygenation level-dependent (BOLD) activation associated with interictal epileptiform discharges in a patient with fixation-off sensitivity (FOS) was studied using a combined electroencephalography-functional magnetic resonance imaging (EEG-fMRI) technique. An automatic approach for combined EEG-fMRI analysis and a subject-specific hemodynamic response function was used to improve general linear model analysis of the fMRI data. The EEG showed the typical features of FOS, with continuous epileptiform discharges during elimination of central vision by eye opening and closing and fixation; modification of this pattern was clearly visible and recognizable. During all 3 recording sessions EEG-fMRI activations indicated a BOLD signal decrease related to epileptiform activity in the parietal areas. This study can further our understanding of this EEG phenomenon and can provide some insight into the reliability of the EEG-fMRI technique in localizing the irritative zone.
| Original language | English |
|---|---|
| Pages (from-to) | 212-217 |
| Number of pages | 6 |
| Journal | Clinical EEG and Neuroscience |
| Volume | 45 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- EEG-fMRI
- Fixation-off sensitivity
- Hemodynamic response function (HRF)
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Reproducibility of EEG-fMRI results in a patient with fixation-off sensitivity. / Formaggio, Emanuela; Storti, Silvia Francesca; Galazzo, Ilaria Boscolo; Bongiovanni, Luigi Giuseppe; Cerini, Roberto; Fiaschi, Antonio; Manganotti, Paolo.
In: Clinical EEG and Neuroscience, Vol. 45, No. 3, 2014, p. 212-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reproducibility of EEG-fMRI results in a patient with fixation-off sensitivity
AU - Formaggio, Emanuela
AU - Storti, Silvia Francesca
AU - Galazzo, Ilaria Boscolo
AU - Bongiovanni, Luigi Giuseppe
AU - Cerini, Roberto
AU - Fiaschi, Antonio
AU - Manganotti, Paolo
PY - 2014
Y1 - 2014
N2 - Blood oxygenation level-dependent (BOLD) activation associated with interictal epileptiform discharges in a patient with fixation-off sensitivity (FOS) was studied using a combined electroencephalography-functional magnetic resonance imaging (EEG-fMRI) technique. An automatic approach for combined EEG-fMRI analysis and a subject-specific hemodynamic response function was used to improve general linear model analysis of the fMRI data. The EEG showed the typical features of FOS, with continuous epileptiform discharges during elimination of central vision by eye opening and closing and fixation; modification of this pattern was clearly visible and recognizable. During all 3 recording sessions EEG-fMRI activations indicated a BOLD signal decrease related to epileptiform activity in the parietal areas. This study can further our understanding of this EEG phenomenon and can provide some insight into the reliability of the EEG-fMRI technique in localizing the irritative zone.
AB - Blood oxygenation level-dependent (BOLD) activation associated with interictal epileptiform discharges in a patient with fixation-off sensitivity (FOS) was studied using a combined electroencephalography-functional magnetic resonance imaging (EEG-fMRI) technique. An automatic approach for combined EEG-fMRI analysis and a subject-specific hemodynamic response function was used to improve general linear model analysis of the fMRI data. The EEG showed the typical features of FOS, with continuous epileptiform discharges during elimination of central vision by eye opening and closing and fixation; modification of this pattern was clearly visible and recognizable. During all 3 recording sessions EEG-fMRI activations indicated a BOLD signal decrease related to epileptiform activity in the parietal areas. This study can further our understanding of this EEG phenomenon and can provide some insight into the reliability of the EEG-fMRI technique in localizing the irritative zone.
KW - EEG-fMRI
KW - Fixation-off sensitivity
KW - Hemodynamic response function (HRF)
UR - http://www.scopus.com/inward/record.url?scp=84906542157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906542157&partnerID=8YFLogxK
U2 - 10.1177/1550059413497946
DO - 10.1177/1550059413497946
M3 - Article
C2 - 24048241
AN - SCOPUS:84906542157
VL - 45
SP - 212
EP - 217
JO - Clinical EEG and Neuroscience
JF - Clinical EEG and Neuroscience
SN - 1550-0594
IS - 3
ER -