Reproducibility of macular thickness measurements using cirrus SD-OCT in neovascular age-related macular degeneration

Mariacristina Parravano, Francesco Oddone, Barbara Boccassini, Francesca Menchini, Adele Chiaravalloti, Mauro Schiavone, Monica Varano

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE. To assess the test-retest variability of central and sectorial macular thickness measurements obtained by Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) in neovascular agerelated macular degeneration (nAMD). METHODS. Macular thickness measurements of nine standard ETDRS subfields were obtained and analyzed. The repeatability of macular thickness measurements by Cirrus HD-OCT was assessed by examining the intrasession within subject standard deviation (Sw), coefficient of repeatability (CR), and coefficient of variation (CV), before and after eyes with retinal segmentation errors were excluded. RESULTS. Forty-nine nAMD eyes of 49 consecutive patients were included in the study. The CR for the central macular subfield was 42.4 μm (10.5%) and ranged from 12.1 μm (3.7%) for the outer nasal to 41.8 μm (11.4%) for the inner nasal subfields. In a secondary analysis, eyes affected by erroneous detection of inner and outer retinal boundaries (6/49, 12.24%) were excluded. The revised coefficient of repeatability for the central macular subfield was 26.1 μm (8.1%) and ranged from 10.3 μm (3.8%) for the outer superior to 30.2 μm (8.3%) for the inner nasal subfields. CONCLUSIONS. Overall, the test-retest variability of Cirrus HDOCT is good for the central and sectorial macular subfields, with a low incidence of scan artifacts.

Original languageEnglish
Pages (from-to)4788-4791
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number9
DOIs
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Reproducibility of macular thickness measurements using cirrus SD-OCT in neovascular age-related macular degeneration'. Together they form a unique fingerprint.

Cite this