Reproducibility of the external surface position in left-breast DIBH radiotherapy with spirometer-based monitoring.

Aurora Fassi, Giovanni B. Ivaldi, Ilaria Meaglia, Patrizia Porcu, Paola Tabarelli de Fatis, Marco Liotta, Marco Riboldi, Guido Baroni

Research output: Contribution to journalArticle

Abstract

Deep inspiration breath hold (DIBH) in left-sided breast cancer radiotherapy treatments allows for a reduction in cardiac and pulmonary doses without compromising target coverage. The selection of the most appropriate technology for DIBH monitoring is a crucial issue. We evaluated the stability and reproducibility of DIBHs controlled by a spirometric device, by assessing the variability of the external surface position within a single DIBH (intra-DIBH) and between DIBHs performed in the same treatment session (intrafraction) or in different sessions (interfraction). The study included seven left-breast cancer patients treated with spirometer-based DIBH radiotherapy. Infrared optical tracking was used to record the 3D coordinates of seven to eleven passive markers placed on the patient's thoraco-abdominal surface during 29-43 DIBHs performed in six to eight treatment sessions. The obtained results showed displacements of the external surface between different sessions up to 6.3mm along a single direction, even at constant inspired volumes. The median value of the interfraction variability in the position of breast passive markers was 2.9 mm (range 1.9-4.8 mm) in the latero-lateral direction, 3.6 mm (range 2.2-4.6mm) in the antero-posterior direction, and 4.3mm (range 2.8-6.2 mm) in the cranio-caudal direction. There were no significant dose distribution variations for target and organs at risk with respect to the treatment plan, confirming the adequacy of the applied clinical margins (15 mm) to compensate for the measured setup uncertainties. This study demonstrates that spirometer-based control does not guarantee a stable and reproducible position of the external surface in left-breast DIBH radiotherapy, suggesting the need for more robust DIBH monitoring techniques when reduced margins and setup uncertainties are required for improving normal tissue sparing and decreasing cardiac and pulmonary toxicity.

Original languageEnglish
Pages (from-to)4494
Number of pages1
JournalJournal of Applied Clinical Medical Physics
Volume15
Issue number1
Publication statusPublished - 2014

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spirometers
inspiration
Radiotherapy
breast
radiation therapy
Breast
Monitoring
Uncertainty
Organs at Risk
Lung
markers
Therapeutics
margins
infrared tracking
Toxicity
cancer
optical tracking
dosage
Tissue
Breast Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Reproducibility of the external surface position in left-breast DIBH radiotherapy with spirometer-based monitoring. / Fassi, Aurora; Ivaldi, Giovanni B.; Meaglia, Ilaria; Porcu, Patrizia; Tabarelli de Fatis, Paola; Liotta, Marco; Riboldi, Marco; Baroni, Guido.

In: Journal of Applied Clinical Medical Physics, Vol. 15, No. 1, 2014, p. 4494.

Research output: Contribution to journalArticle

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