Reproducibility of the six-minute walking test in chronic heart failure patients

Gian Domenico Pinna, Cristina Opasich, Antonio Mazza, Antonio Tangenti, Roberto Maestri, Maurizio Sanarico

Research output: Contribution to journalArticlepeer-review


The six-minute walking test (WT) is used in trials and clinical practice as an easy tool to evaluate the functional capacity of chronic heart failure (CHF) patients. As WT measurements are highly variable both between and within individuals, this study aims at assessing the contribution of the different sources of variation and estimating the reproducibility of the test. A statistical model describing WT measurements as a function of fixed and random effects is proposed and its parameters estimated. We considered 202 stable CHF patients who performed two baseline WTs separated by a 30 minute rest; 49 of them repeated the two tests 3 months later (follow-up control). They had no changes in therapy or major clinical events. Another 31 subjects performed two baseline tests separated by 24 hours. Collected data were analysed using a mixed model methodology. There was no significant difference between measurements taken 30 minutes and 24 hours apart (p=0.99). A trend effect of 17 (1.4) m (mean (SE)) was consistently found between duplicate tests (p

Original languageEnglish
Pages (from-to)3087-3094
Number of pages8
JournalStatistics in Medicine
Issue number22
Publication statusPublished - Nov 30 2000

ASJC Scopus subject areas

  • Epidemiology


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