Reproducibilty of magnetization transfer ratio histogram-derived measures of the brain in healthy volunteers

Maria P. Sormani, Giuseppe Iannucci, Maria A. Rocca, Giovanna Mastronardo, Mara Cercignani, Luca Minicucci, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Using two MR scanners, we evaluated the intraobserver, interobserver, image-reimage, and interimager variabilities in the assessment of magnetization transfer ratio (MTR) histograms obtained monthly on four occasions from five healthy volunteers. With multiple observers, the mean coefficients of variations ranged from 2.2% to 8.2% for 'pure' image-reimage variability, from 1.2% to 4.9% for interobserver variability, and from 2.1% to 4.9% for image-reimage variability. The mean intraobserver coefficients of variations were always lower than 1%. The mean coefficients of variations ranged from 10.2% to 14.6% for pure interimager variability and from 8.6% to 14.3% for interimager variability with multiple observers. Interimager variability accounted for 96.0% of the overall variability of average MTR, for 96.7% of peak location, and for 41.1% of the peak height. The use of different MR scanners is the main source of variability when obtaining MTR histograms.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume21
Issue number1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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