Reproductive and hormonal factors, family history, and breast cancer according to the hormonal receptor status

Valentina Rosato, Cristina Bosetti, Eva Negri, Renato Talamini, Luigino Dal Maso, Matteo Malvezzi, Fabio Falcini, Maurizio Montella, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the association between breast cancer risk, reproductive factors, and family history of breast cancer by the estrogen receptor (ER) and progesterone receptor (PR) status. We analyzed data from an Italian case-control study including 1075 women with incident breast cancer and 1477 hospital controls. We estimated the odds ratios (ORs) of breast cancer using unconditional logistic regression models including major recognized risk factors for breast cancer. Stronger associations with ER+ than with ER-breast cancer were observed for parity (OR: 0.7 vs. 0.9 for ≥3 births vs. nulliparae), age at first birth (OR: 1.6 vs. 1.2 for age ≥30 vs.

Original languageEnglish
Pages (from-to)412-417
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume23
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • breast cancer
  • case-control study
  • family history
  • hormonal factors
  • hormonal receptor status
  • reproductive factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

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